Detailed information of TA system TA026163

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 2253510..2254174
• Replicon: chromosome
• Accession: NC_016946
• Organism: Mycobacterium intracellulare ATCC 13950

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: H8IUS5
• Locus tag: OCU_RS35535
• Protein ID: WP_014379897.1
• Coordinates: 2253767..2254174 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: OCU_RS50400
• Protein ID: WP_009954496.1
• Coordinates: 2253510..2253770 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCU_RS35515	2250027..2250518	-	492	WP_014379893.1	DUF1707 domain-containing protein	-
OCU_RS35520	2250588..2251184	+	597	WP_009954492.1	TetR/AcrR family transcriptional regulator	-
OCU_RS35525	2251189..2252457	-	1269	WP_014379895.1	cytochrome P450	-
OCU_RS35530	2252615..2253067	+	453	WP_014379896.1	VOC family protein	-
OCU_RS50395	2253099..2253387	+	289	Protein_2102	hypothetical protein	-
OCU_RS50400	2253510..2253770	+	261	WP_009954496.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
OCU_RS35535	2253767..2254174	+	408	WP_014379897.1	type II toxin-antitoxin system VapC family toxin	Toxin
OCU_RS35540	2254352..2257453	+	3102	WP_014379898.1	DEAD/DEAH box helicase	-
OCU_RS35545	2257514..2259079	-	1566	WP_014379899.1	serine/threonine protein kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-125)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-66)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14307.31 Da
• Isoelectric Point: 4.2772

>T26163 WP_014379897.1 NC_016946:2253767-2254174 [Mycobacterium intracellulare ATCC 13950]
MSNPQVAGVLDTSVFIATESGRPLDAALIPDQVGTTVVTLAELHVGVLAASTSDIRAQRLATLESIADIEALPIDDDAAR
MWARLRIHLAETGQRVRINDLWIAAIAASRGLPVVTQDDDFAVLDGAANLTVIRV

Nucleotide

• Length: 408 bp

>T26163 NC_016946:2253767-2254174 [Mycobacterium intracellulare ATCC 13950]
ATGAGCAACCCGCAGGTGGCCGGAGTGCTCGACACTTCGGTGTTCATCGCGACCGAAAGTGGTCGGCCTCTCGACGCGGC
GCTGATCCCTGATCAAGTTGGCACGACGGTTGTTACCCTCGCGGAACTGCACGTTGGTGTGTTGGCCGCGTCGACTTCCG
ATATTAGAGCGCAGCGCCTCGCGACATTGGAATCCATTGCGGATATCGAAGCGCTGCCGATCGATGACGATGCGGCCCGG
ATGTGGGCCCGGCTGCGGATCCATCTCGCCGAGACCGGTCAACGCGTCCGGATCAACGATCTGTGGATCGCGGCCATCGC
GGCGTCCCGAGGGCTACCCGTTGTCACGCAGGACGATGACTTTGCCGTCTTGGATGGTGCGGCCAATTTGACCGTTATCC
GCGTCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9526.85 Da
• Isoelectric Point: 9.1203

>AT26163 WP_009954496.1 NC_016946:2253510-2253770 [Mycobacterium intracellulare ATCC 13950]
MSEVASRELRNDTAGVLRRVRDGEDVTITVSGRPVAVLTAVVPQRRRWLSKTELLSRLPRVQADPGLREDLHALAGDTTE
ELGPIR

Nucleotide

• Length: 261 bp

>AT26163 NC_016946:2253510-2253770 [Mycobacterium intracellulare ATCC 13950]
ATGTCTGAAGTGGCATCTCGTGAGCTGCGCAACGATACGGCTGGGGTGCTGCGGCGGGTTCGGGATGGAGAGGACGTCAC
CATCACTGTCAGTGGCCGACCGGTCGCAGTTCTTACCGCAGTTGTCCCTCAGCGCAGGCGTTGGCTGAGCAAGACGGAGT
TGCTGTCGCGCTTGCCCCGCGTTCAAGCGGATCCGGGATTACGCGAGGACCTTCACGCACTCGCCGGCGACACTACCGAG
GAGCTGGGCCCGATCCGATGA

Structures

Toxin

• AlphaFold DB: A0A7R7MTD0