Detailed information of TA system TA026162

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1139979..1140543
• Replicon: chromosome
• Accession: NC_016946
• Organism: Mycobacterium intracellulare ATCC 13950

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: H8IVI4
• Locus tag: OCU_RS30615
• Protein ID: WP_009953437.1
• Coordinates: 1140172..1140543 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: OCU_RS30610
• Protein ID: WP_026071432.1
• Coordinates: 1139979..1140185 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCU_RS30590	1135600..1136598	+	999	WP_008254378.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
OCU_RS30595	1136644..1137783	-	1140	WP_179293415.1	hypothetical protein	-
OCU_RS30600	1137925..1138998	+	1074	WP_009953440.1	redox-regulated ATPase YchF	-
OCU_RS30605	1139078..1139740	-	663	WP_014379386.1	methyltransferase domain-containing protein	-
OCU_RS30610	1139979..1140185	+	207	WP_026071432.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
OCU_RS30615	1140172..1140543	+	372	WP_009953437.1	type II toxin-antitoxin system VapC family toxin	Toxin
OCU_RS30620	1140601..1141152	+	552	WP_009953436.1	VOC family protein	-
OCU_RS30625	1141231..1141629	+	399	WP_009953435.1	VOC family protein	-
OCU_RS30630	1141728..1142111	+	384	WP_026071433.1	hypothetical protein	-
OCU_RS51490	1142197..1142556	+	360	WP_179293417.1	hypothetical protein	-
OCU_RS30640	1142738..1143313	+	576	WP_085977620.1	C40 family peptidase	-
OCU_RS30645	1143676..1143999	+	324	WP_009953431.1	antibiotic biosynthesis monooxygenase	-
OCU_RS30650	1144048..1144731	-	684	WP_014384004.1	hypothetical protein	-
OCU_RS50200	1144878..1145087	+	210	WP_014381976.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13868.20 Da
• Isoelectric Point: 6.8398

>T26162 WP_009953437.1 NC_016946:1140172-1140543 [Mycobacterium intracellulare ATCC 13950]
VILVDTSIWIDHLHVAEQRLVGRLTNDEIGCHQMVIEELALGMIKQRDDVLRLLSHLREFPLLTHAEILHLVDRRRLWGR
GLSAIDAHLLGSVAVVDGARLWTRDKKLKAACKEVGVAIVDES

Nucleotide

• Length: 372 bp

>T26162 NC_016946:1140172-1140543 [Mycobacterium intracellulare ATCC 13950]
GTGATCCTCGTTGACACATCGATATGGATTGACCATCTGCACGTCGCCGAGCAGCGCCTCGTCGGCCGCTTGACCAACGA
CGAAATCGGTTGCCACCAAATGGTGATCGAGGAGCTGGCACTCGGTATGATCAAGCAGCGCGACGACGTACTGAGATTGC
TGTCCCATCTGCGCGAGTTTCCGTTGTTGACGCACGCGGAAATCCTCCATCTCGTTGACCGTCGCCGCTTGTGGGGAAGG
GGATTGAGTGCAATCGACGCCCACCTTCTTGGGTCGGTTGCTGTCGTCGACGGTGCACGGCTTTGGACGAGGGACAAGAA
GTTGAAAGCGGCGTGTAAAGAAGTGGGTGTTGCGATCGTCGATGAGTCGTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7250.31 Da
• Isoelectric Point: 11.9169

>AT26162 WP_026071432.1 NC_016946:1139979-1140185 [Mycobacterium intracellulare ATCC 13950]
MRTTVTIDDALLAQAAELTGVTESAALLRQGLQTLIRVESARRLAALGGTDPKASAAPRRRPPTRDPR

Nucleotide

• Length: 207 bp

>AT26162 NC_016946:1139979-1140185 [Mycobacterium intracellulare ATCC 13950]
ATGAGGACAACAGTGACCATCGACGATGCCTTACTGGCTCAGGCGGCGGAACTGACCGGCGTGACGGAGAGTGCGGCGCT
TCTCCGTCAGGGATTGCAGACCCTCATTCGGGTAGAGAGCGCCCGCCGTCTCGCGGCGCTCGGCGGCACGGACCCCAAGG
CGTCGGCCGCCCCGCGGCGGAGGCCGCCGACCCGTGATCCTCGTTGA

Structures

Toxin

• AlphaFold DB: A0A7R7MQX9