261618

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2755269..2756857 Replicon chromosome
Accession NZ_CP107503
Organism Klebsiella pneumoniae strain CRKP_4

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag OH526_RS13665 Protein ID WP_004199851.1
Coordinates 2755269..2756591 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag OH526_RS13670 Protein ID WP_002904790.1
Coordinates 2756591..2756857 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH526_RS13650 2750334..2752835 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
OH526_RS13655 2752823..2753827 + 1005 WP_004199852.1 fimbrial protein -
OH526_RS13660 2753960..2755252 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OH526_RS13665 2755269..2756591 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
OH526_RS13670 2756591..2756857 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OH526_RS13675 2757123..2757449 - 327 WP_002904788.1 hydroxyisourate hydrolase -
OH526_RS13680 2757446..2757946 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OH526_RS13685 2757924..2759303 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
OH526_RS13690 2759649..2760803 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OH526_RS13695 2760784..2761707 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(149-402)

Antitoxin

(16-65)


Sequences


Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T261618 WP_004199851.1 NZ_CP107503:c2756591-2755269 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT261618 WP_002904790.1 NZ_CP107503:c2756857-2756591 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References