Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 149205..149950 Replicon plasmid unnamed1
Accession NZ_CP107494
Organism Klebsiella pneumoniae strain CRKP_6

Toxin (Protein)


Gene name tacT Uniprot ID A0A331KSM6
Locus tag OH495_RS27775 Protein ID WP_032408901.1
Coordinates 149205..149696 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag OH495_RS27780 Protein ID WP_014386183.1
Coordinates 149684..149950 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH495_RS27750 144889..145644 + 756 WP_032408898.1 DeoR/GlpR family DNA-binding transcription regulator -
OH495_RS27755 145906..146346 + 441 WP_014386179.1 transposase -
OH495_RS27760 146343..146693 + 351 WP_014386180.1 IS66 family insertion sequence element accessory protein TnpB -
OH495_RS27765 146724..148316 + 1593 Protein_162 IS66 family transposase -
OH495_RS27770 148513..148764 + 252 WP_032408900.1 aldo/keto reductase -
OH495_RS27775 149205..149696 - 492 WP_032408901.1 GNAT family N-acetyltransferase Toxin
OH495_RS27780 149684..149950 - 267 WP_014386183.1 DUF1778 domain-containing protein Antitoxin
OH495_RS27785 150186..150305 + 120 WP_223156217.1 type I toxin-antitoxin system Hok family toxin -
OH495_RS27790 150549..151034 - 486 WP_014386185.1 hypothetical protein -
OH495_RS27795 151224..151496 + 273 WP_032408902.1 hypothetical protein -
OH495_RS27800 151493..151843 + 351 WP_014386186.1 hypothetical protein -
OH495_RS27805 152480..152806 + 327 WP_014386187.1 hypothetical protein -
OH495_RS27810 152868..153080 + 213 WP_014386188.1 hypothetical protein -
OH495_RS27815 153091..153315 + 225 WP_014386189.1 hypothetical protein -
OH495_RS27820 153396..153716 + 321 WP_014386190.1 type II toxin-antitoxin system RelE/ParE family toxin -
OH495_RS27825 153706..153984 + 279 WP_004152721.1 helix-turn-helix transcriptional regulator -
OH495_RS27830 153985..154398 + 414 WP_013023817.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(A) / sul1 / qacE / aadA2 / dfrA12 / aph(3')-Ia - 1..205641 205641


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(89-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17667.46 Da        Isoelectric Point: 8.8757

>T261575 WP_032408901.1 NZ_CP107494:c149696-149205 [Klebsiella pneumoniae]
VGKVTAPVPLGTSHILAEFHCGEPVLDEWIKHRGLKNQSLGAARTFVVCRGNASQVLAYYSLATGSVTHAIAPGSLRRNM
PDPVPVIILARLAVDTSYHGQGLGADLLHDAVLRCCRVAENIGVRAVMVHALSDSARQFYIHHGFIPSQTQDRTLFLRLP
LIT

Download         Length: 492 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.66 Da        Isoelectric Point: 5.1169

>AT261575 WP_014386183.1 NZ_CP107494:c149950-149684 [Klebsiella pneumoniae]
MKSDVQLNIRAKEAQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIDMLDAPVTANPAMEKLL
ARKPQWAK

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331KSM6

Antitoxin

Source ID Structure

References