261568

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4189378..4189997 Replicon chromosome
Accession NZ_CP107493
Organism Klebsiella pneumoniae strain CRKP_6

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag OH495_RS20855 Protein ID WP_002892050.1
Coordinates 4189779..4189997 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag OH495_RS20850 Protein ID WP_002892066.1
Coordinates 4189378..4189752 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH495_RS20840 4184530..4185723 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OH495_RS20845 4185746..4188892 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
OH495_RS20850 4189378..4189752 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
OH495_RS20855 4189779..4189997 + 219 WP_002892050.1 HHA domain-containing protein Toxin
OH495_RS20860 4190156..4190722 + 567 WP_002892030.1 maltose O-acetyltransferase -
OH495_RS20865 4190694..4190834 - 141 WP_004147370.1 hypothetical protein -
OH495_RS20870 4190855..4191325 + 471 WP_002892026.1 YlaC family protein -
OH495_RS20875 4191300..4192751 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
OH495_RS20880 4192852..4193550 + 699 WP_002892021.1 GNAT family protein -
OH495_RS20885 4193547..4193687 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
OH495_RS20890 4193687..4193950 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T261568 WP_002892050.1 NZ_CP107493:4189779-4189997 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT261568 WP_002892066.1 NZ_CP107493:4189378-4189752 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References