261523

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 149200..149945 Replicon plasmid unnamed1
Accession NZ_CP107484
Organism Klebsiella pneumoniae strain CRKP_8

Toxin (Protein)


Gene name tacT Uniprot ID A0A331KSM6
Locus tag OH502_RS27785 Protein ID WP_032408901.1
Coordinates 149200..149691 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag OH502_RS27790 Protein ID WP_014386183.1
Coordinates 149679..149945 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH502_RS27760 144884..145639 + 756 WP_032408898.1 DeoR/GlpR family DNA-binding transcription regulator -
OH502_RS27765 145901..146341 + 441 WP_014386179.1 transposase -
OH502_RS27770 146338..146688 + 351 WP_014386180.1 IS66 family insertion sequence element accessory protein TnpB -
OH502_RS27775 146719..148311 + 1593 Protein_162 IS66 family transposase -
OH502_RS27780 148508..148759 + 252 WP_032408900.1 aldo/keto reductase -
OH502_RS27785 149200..149691 - 492 WP_032408901.1 GNAT family N-acetyltransferase Toxin
OH502_RS27790 149679..149945 - 267 WP_014386183.1 DUF1778 domain-containing protein Antitoxin
OH502_RS27795 150181..150300 + 120 WP_223156217.1 type I toxin-antitoxin system Hok family toxin -
OH502_RS27800 150544..151029 - 486 WP_014386185.1 hypothetical protein -
OH502_RS27805 151219..151491 + 273 WP_032408902.1 hypothetical protein -
OH502_RS27810 151488..151838 + 351 WP_014386186.1 hypothetical protein -
OH502_RS27815 152475..152801 + 327 WP_014386187.1 hypothetical protein -
OH502_RS27820 152863..153075 + 213 WP_014386188.1 hypothetical protein -
OH502_RS27825 153086..153310 + 225 WP_014386189.1 hypothetical protein -
OH502_RS27830 153391..153711 + 321 WP_014386190.1 type II toxin-antitoxin system RelE/ParE family toxin -
OH502_RS27835 153701..153979 + 279 WP_004152721.1 helix-turn-helix transcriptional regulator -
OH502_RS27840 153980..154393 + 414 WP_013023817.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(A) / sul1 / qacE / aadA2 / dfrA12 / aph(3')-Ia - 1..205636 205636


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(89-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17667.46 Da        Isoelectric Point: 8.8757

>T261523 WP_032408901.1 NZ_CP107484:c149691-149200 [Klebsiella pneumoniae]
VGKVTAPVPLGTSHILAEFHCGEPVLDEWIKHRGLKNQSLGAARTFVVCRGNASQVLAYYSLATGSVTHAIAPGSLRRNM
PDPVPVIILARLAVDTSYHGQGLGADLLHDAVLRCCRVAENIGVRAVMVHALSDSARQFYIHHGFIPSQTQDRTLFLRLP
LIT

Download         Length: 492 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.66 Da        Isoelectric Point: 5.1169

>AT261523 WP_014386183.1 NZ_CP107484:c149945-149679 [Klebsiella pneumoniae]
MKSDVQLNIRAKEAQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIDMLDAPVTANPAMEKLL
ARKPQWAK

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331KSM6

Antitoxin

Source ID Structure

References