Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 149110..149855 Replicon plasmid unnamed1
Accession NZ_CP107479
Organism Klebsiella pneumoniae strain CRKP_9

Toxin (Protein)


Gene name tacT Uniprot ID A0A331KSM6
Locus tag OH537_RS27770 Protein ID WP_032408901.1
Coordinates 149110..149601 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag OH537_RS27775 Protein ID WP_014386183.1
Coordinates 149589..149855 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH537_RS27745 144794..145549 + 756 WP_032408898.1 DeoR/GlpR family DNA-binding transcription regulator -
OH537_RS27750 145811..146251 + 441 WP_014386179.1 transposase -
OH537_RS27755 146248..146598 + 351 WP_014386180.1 IS66 family insertion sequence element accessory protein TnpB -
OH537_RS27760 146629..148221 + 1593 Protein_162 IS66 family transposase -
OH537_RS27765 148418..148669 + 252 WP_032408900.1 aldo/keto reductase -
OH537_RS27770 149110..149601 - 492 WP_032408901.1 GNAT family N-acetyltransferase Toxin
OH537_RS27775 149589..149855 - 267 WP_014386183.1 DUF1778 domain-containing protein Antitoxin
OH537_RS27780 150091..150210 + 120 WP_223156217.1 type I toxin-antitoxin system Hok family toxin -
OH537_RS27785 150454..150939 - 486 WP_014386185.1 hypothetical protein -
OH537_RS27790 151129..151401 + 273 WP_032408902.1 hypothetical protein -
OH537_RS27795 151398..151748 + 351 WP_014386186.1 hypothetical protein -
OH537_RS27800 152385..152711 + 327 WP_014386187.1 hypothetical protein -
OH537_RS27805 152773..152985 + 213 WP_014386188.1 hypothetical protein -
OH537_RS27810 152996..153220 + 225 WP_014386189.1 hypothetical protein -
OH537_RS27815 153301..153621 + 321 WP_014386190.1 type II toxin-antitoxin system RelE/ParE family toxin -
OH537_RS27820 153611..153889 + 279 WP_004152721.1 helix-turn-helix transcriptional regulator -
OH537_RS27825 153890..154303 + 414 WP_013023817.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(A) / sul1 / qacE / aadA2 / dfrA12 / aph(3')-Ia - 1..205545 205545


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(89-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17667.46 Da        Isoelectric Point: 8.8757

>T261497 WP_032408901.1 NZ_CP107479:c149601-149110 [Klebsiella pneumoniae]
VGKVTAPVPLGTSHILAEFHCGEPVLDEWIKHRGLKNQSLGAARTFVVCRGNASQVLAYYSLATGSVTHAIAPGSLRRNM
PDPVPVIILARLAVDTSYHGQGLGADLLHDAVLRCCRVAENIGVRAVMVHALSDSARQFYIHHGFIPSQTQDRTLFLRLP
LIT

Download         Length: 492 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.66 Da        Isoelectric Point: 5.1169

>AT261497 WP_014386183.1 NZ_CP107479:c149855-149589 [Klebsiella pneumoniae]
MKSDVQLNIRAKEAQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIDMLDAPVTANPAMEKLL
ARKPQWAK

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331KSM6

Antitoxin

Source ID Structure

References