Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2173559..2174075 Replicon chromosome
Accession NZ_CP107473
Organism Klebsiella pneumoniae strain CRKP_10

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag OH522_RS10745 Protein ID WP_002886902.1
Coordinates 2173559..2173843 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OH522_RS10750 Protein ID WP_002886901.1
Coordinates 2173833..2174075 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH522_RS10720 2169043..2169351 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
OH522_RS10725 2169436..2169609 + 174 WP_002886906.1 hypothetical protein -
OH522_RS10730 2169612..2170355 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OH522_RS10735 2170712..2172850 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
OH522_RS10740 2173091..2173555 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OH522_RS10745 2173559..2173843 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OH522_RS10750 2173833..2174075 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OH522_RS10755 2174153..2176063 - 1911 WP_004152270.1 PRD domain-containing protein -
OH522_RS10760 2176086..2177240 - 1155 WP_002886900.1 lactonase family protein -
OH522_RS10765 2177306..2178046 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T261459 WP_002886902.1 NZ_CP107473:c2173843-2173559 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT261459 WP_002886901.1 NZ_CP107473:c2174075-2173833 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References