Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5059982..5061663 Replicon chromosome
Accession NZ_CP107468
Organism Klebsiella pneumoniae strain CRKP_11

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag OH523_RS25065 Protein ID WP_002885155.1
Coordinates 5059982..5060899 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag OH523_RS25070 Protein ID WP_004151732.1
Coordinates 5060905..5061663 (-) Length 253 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH523_RS25045 5055288..5056808 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
OH523_RS25050 5056805..5057803 + 999 WP_002885172.1 ribose ABC transporter permease -
OH523_RS25055 5057834..5058775 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
OH523_RS25060 5058850..5059857 + 1008 WP_004151731.1 carbohydrate kinase family protein -
OH523_RS25065 5059982..5060899 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
OH523_RS25070 5060905..5061663 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
OH523_RS25075 5061749..5062477 - 729 WP_002885152.1 response regulator transcription factor -
OH523_RS25080 5062750..5064897 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
OH523_RS25085 5065127..5065813 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T261441 WP_002885155.1 NZ_CP107468:c5060899-5059982 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp


Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT261441 WP_004151732.1 NZ_CP107468:c5061663-5060905 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References