261438

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4188527..4189146 Replicon chromosome
Accession NZ_CP107468
Organism Klebsiella pneumoniae strain CRKP_11

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag OH523_RS20835 Protein ID WP_002892050.1
Coordinates 4188928..4189146 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag OH523_RS20830 Protein ID WP_002892066.1
Coordinates 4188527..4188901 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH523_RS20820 4183679..4184872 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OH523_RS20825 4184895..4188041 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
OH523_RS20830 4188527..4188901 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
OH523_RS20835 4188928..4189146 + 219 WP_002892050.1 HHA domain-containing protein Toxin
OH523_RS20840 4189305..4189871 + 567 WP_002892030.1 maltose O-acetyltransferase -
OH523_RS20845 4189843..4189983 - 141 WP_004147370.1 hypothetical protein -
OH523_RS20850 4190004..4190474 + 471 WP_002892026.1 YlaC family protein -
OH523_RS20855 4190449..4191900 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
OH523_RS20860 4192001..4192699 + 699 WP_002892021.1 GNAT family protein -
OH523_RS20865 4192696..4192836 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
OH523_RS20870 4192836..4193099 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T261438 WP_002892050.1 NZ_CP107468:4188928-4189146 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT261438 WP_002892066.1 NZ_CP107468:4188527-4188901 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References