Detailed information of TA system TA026141

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-YefM
• Location: 4604454..4604989
• Replicon: chromosome
• Accession: NC_016943
• Organism: Blastococcus saxobsidens DD2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BLASA_RS21835
• Protein ID: WP_197536368.1
• Coordinates: 4604729..4604989 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: H6RT76
• Locus tag: BLASA_RS21830
• Protein ID: WP_014378442.1
• Coordinates: 4604454..4604741 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BLASA_RS21805	4599642..4600268	-	627	WP_014378437.1	CDP-alcohol phosphatidyltransferase family protein	-
BLASA_RS21810	4600395..4601645	+	1251	WP_014378438.1	ABC transporter substrate-binding protein	-
BLASA_RS21815	4601698..4602516	+	819	WP_014378439.1	ABC transporter permease subunit	-
BLASA_RS24680	4602513..4603301	+	789	WP_197536244.1	ABC transporter permease subunit	-
BLASA_RS21825	4603298..4604398	+	1101	WP_014378441.1	ABC transporter ATP-binding protein	-
BLASA_RS21830	4604454..4604741	+	288	WP_014378442.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BLASA_RS21835	4604729..4604989	+	261	WP_197536368.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BLASA_RS21840	4605368..4605661	+	294	WP_051005253.1	cupin domain-containing protein	-
BLASA_RS21845	4605658..4607067	-	1410	WP_041776856.1	hypothetical protein	-
BLASA_RS21850	4607154..4608692	-	1539	WP_014378446.1	NAD(P)/FAD-dependent oxidoreductase	-
BLASA_RS21855	4608689..4609987	-	1299	WP_014378447.1	amidohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (19-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 9905.25 Da
• Isoelectric Point: 8.9814

>T26141 WP_197536368.1 NC_016943:4604729-4604989 [Blastococcus saxobsidens DD2]
IDWVTFYIVVTRTAGRQLAERLSESAATACVEFLFGPLADEPHRVGAPLRAPFTGQWRARRGEYRVRYRIDDANGIVYVL
DIDHRR

Nucleotide

• Length: 261 bp

>T26141 NC_016943:4604729-4604989 [Blastococcus saxobsidens DD2]
ATCGACTGGGTGACCTTTTACATCGTGGTGACCCGGACGGCCGGACGGCAGCTCGCCGAACGCCTATCGGAGTCAGCTGC
CACAGCATGCGTCGAGTTCTTGTTCGGCCCGTTGGCAGACGAGCCGCATCGCGTCGGTGCGCCGCTGCGTGCCCCGTTCA
CCGGTCAATGGCGCGCGCGCCGAGGCGAGTACCGCGTCCGCTATCGCATCGATGATGCGAACGGCATCGTCTACGTGCTC
GACATCGATCACCGAAGGTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10386.60 Da
• Isoelectric Point: 4.5925

>AT26141 WP_014378442.1 NC_016943:4604454-4604741 [Blastococcus saxobsidens DD2]
MTTLPLSEVKARLSEIAEGVATTHERVQITKNGRDYVVLLAAEDLESIEATLELLSDHDARSRVARAEEDIERGNVLDEA
QVRALLTARRSGSTG

Nucleotide

• Length: 288 bp

>AT26141 NC_016943:4604454-4604741 [Blastococcus saxobsidens DD2]
ATGACTACCCTGCCGCTGTCCGAGGTGAAGGCGCGCCTGTCGGAGATCGCCGAAGGCGTAGCGACGACGCATGAGCGTGT
CCAGATCACCAAGAACGGGCGCGACTACGTGGTGCTCCTTGCCGCCGAGGACCTCGAGTCCATCGAGGCCACCCTCGAGT
TGCTCAGCGACCACGATGCTCGGTCGCGCGTGGCCCGCGCCGAGGAGGACATCGAGCGGGGGAACGTGCTGGACGAGGCC
CAGGTGCGCGCGCTGCTCACCGCGCGGCGGTCCGGATCGACTGGGTGA

Structures

Antitoxin

• AlphaFold DB: H6RT76