261393

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5467406..5468031 Replicon chromosome
Accession NZ_CP107458
Organism Klebsiella pneumoniae strain CRKP_13

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OH496_RS26935 Protein ID WP_002882817.1
Coordinates 5467406..5467789 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OH496_RS26940 Protein ID WP_004150355.1
Coordinates 5467789..5468031 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH496_RS26920 5464772..5465674 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OH496_RS26925 5465671..5466306 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OH496_RS26930 5466303..5467232 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OH496_RS26935 5467406..5467789 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OH496_RS26940 5467789..5468031 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OH496_RS26945 5468236..5469153 + 918 WP_002882812.1 alpha/beta hydrolase -
OH496_RS26950 5469167..5470108 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OH496_RS26955 5470153..5470590 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OH496_RS26960 5470587..5471447 - 861 WP_002882807.1 virulence factor BrkB family protein -
OH496_RS26965 5471441..5472040 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T261393 WP_002882817.1 NZ_CP107458:c5467789-5467406 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT261393 WP_004150355.1 NZ_CP107458:c5468031-5467789 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References