Detailed information of TA system TA026139

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK(toxin)
• Location: 3406066..3406630
• Replicon: chromosome
• Accession: NC_016943
• Organism: Blastococcus saxobsidens DD2

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: BLASA_RS16120
• Protein ID: WP_041775806.1
• Coordinates: 3406066..3406413 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: H6RTY7
• Locus tag: BLASA_RS16125
• Protein ID: WP_014377276.1
• Coordinates: 3406400..3406630 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BLASA_RS16105	3404104..3405309	+	1206	WP_014377272.1	DUF2399 domain-containing protein	-
BLASA_RS16110	3405347..3405598	+	252	WP_197536232.1	type II toxin-antitoxin system CcdA family antitoxin	-
BLASA_RS16115	3405622..3405981	+	360	WP_166486566.1	hypothetical protein	-
BLASA_RS16120	3406066..3406413	-	348	WP_041775806.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
BLASA_RS16125	3406400..3406630	-	231	WP_014377276.1	ribbon-helix-helix protein, CopG family	Antitoxin
BLASA_RS16130	3406662..3409934	-	3273	WP_014377277.1	DEAD/DEAH box helicase	-
BLASA_RS16135	3410043..3410504	-	462	WP_041775807.1	hypothetical protein	-
BLASA_RS16140	3410495..3411082	-	588	WP_041775808.1	MarR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-112)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-37)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12558.55 Da
• Isoelectric Point: 11.5180

>T26139 WP_041775806.1 NC_016943:c3406413-3406066 [Blastococcus saxobsidens DD2]
MRRGEVRLIDLELVRGSEANKRRPAVVVSNDQANATAARLGRGVVTVVPLSSNVQRVFPFQTFLPSTVSGLRVESKAQAE
QVRAVAVERVGPVLGRVPEEHMLVLDDALRLHLAL

Nucleotide

• Length: 348 bp

>T26139 NC_016943:c3406413-3406066 [Blastococcus saxobsidens DD2]
ATGCGTCGCGGTGAAGTGCGCTTGATCGACCTCGAGCTGGTGCGCGGCAGTGAAGCCAACAAGCGCCGGCCGGCCGTCGT
GGTCAGCAACGACCAGGCGAACGCGACCGCCGCACGACTGGGGCGCGGAGTAGTCACCGTGGTCCCGCTGAGCAGCAACG
TCCAGCGGGTCTTCCCCTTCCAGACGTTTCTGCCTTCCACAGTCAGCGGGCTCCGCGTCGAGTCGAAGGCTCAGGCCGAG
CAGGTGCGGGCGGTTGCGGTCGAGCGGGTCGGTCCGGTGCTGGGCCGGGTGCCGGAGGAGCACATGCTGGTGCTCGACGA
CGCCCTGCGCCTGCACCTGGCGCTCTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8343.24 Da
• Isoelectric Point: 4.1127

>AT26139 WP_014377276.1 NC_016943:c3406630-3406400 [Blastococcus saxobsidens DD2]
MKLSVSLTDDDVALLDDYLRRSGLTTRSAVIRRALHLLPQPDLEADYSAAWDEWAASGEQAVWEPATADGIVDASR

Nucleotide

• Length: 231 bp

>AT26139 NC_016943:c3406630-3406400 [Blastococcus saxobsidens DD2]
ATGAAACTCAGCGTCAGCCTGACCGATGACGATGTCGCGCTCCTGGACGACTACCTCCGCCGGTCGGGTCTGACGACGCG
CTCGGCGGTGATCAGGCGCGCGCTCCACCTGCTGCCTCAGCCCGACCTGGAGGCCGACTACAGCGCGGCCTGGGACGAAT
GGGCGGCCTCTGGGGAGCAGGCGGTCTGGGAACCGGCAACGGCCGACGGGATAGTCGATGCGTCGCGGTGA

Structures

Antitoxin

• AlphaFold DB: H6RTY7