Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 61244..61887 Replicon plasmid unnamed2
Accession NZ_CP107454
Organism Klebsiella pneumoniae strain CRKP_14

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag OH499_RS28455 Protein ID WP_001044770.1
Coordinates 61244..61660 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag OH499_RS28460 Protein ID WP_001261282.1
Coordinates 61657..61887 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH499_RS28435 (57347) 57347..57619 - 273 Protein_81 transposase -
OH499_RS28445 (58601) 58601..59623 - 1023 WP_000361404.1 helicase UvrD -
OH499_RS28450 (59608) 59608..61170 - 1563 WP_004206609.1 AAA family ATPase -
OH499_RS28455 (61244) 61244..61660 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
OH499_RS28460 (61657) 61657..61887 - 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OH499_RS28465 (61844) 61844..62305 + 462 WP_014343465.1 hypothetical protein -
OH499_RS28470 (62466) 62466..63410 + 945 WP_011977810.1 hypothetical protein -
OH499_RS28475 (63447) 63447..63839 + 393 WP_011977811.1 hypothetical protein -
OH499_RS28480 (63897) 63897..64418 + 522 WP_013214008.1 hypothetical protein -
OH499_RS28485 (64464) 64464..64667 + 204 WP_011977813.1 hypothetical protein -
OH499_RS28490 (64697) 64697..65701 + 1005 WP_011977814.1 hypothetical protein -
OH499_RS28495 (65885) 65885..66664 + 780 WP_013214009.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaKPC-2 / catA2 / blaCTX-M-65 - 1..96034 96034


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T261379 WP_001044770.1 NZ_CP107454:c61660-61244 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT261379 WP_001261282.1 NZ_CP107454:c61887-61657 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References