Detailed information of TA system TA026137

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-YefM
• Location: 3050231..3050778
• Replicon: chromosome
• Accession: NC_016943
• Organism: Blastococcus saxobsidens DD2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: H6RQ79
• Locus tag: BLASA_RS14470
• Protein ID: WP_014376926.1
• Coordinates: 3050503..3050778 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: H6RQ78
• Locus tag: BLASA_RS14465
• Protein ID: WP_014376925.1
• Coordinates: 3050231..3050506 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BLASA_RS14440	3045743..3046267	-	525	WP_014376920.1	phage tail protein	-
BLASA_RS14445	3046288..3047835	-	1548	WP_014376921.1	phage tail sheath family protein	-
BLASA_RS14450	3047870..3048238	-	369	WP_014376922.1	hypothetical protein	-
BLASA_RS14455	3048235..3048672	-	438	WP_014376923.1	hypothetical protein	-
BLASA_RS14460	3048787..3049470	-	684	WP_014376924.1	response regulator transcription factor	-
BLASA_RS14465	3050231..3050506	+	276	WP_014376925.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BLASA_RS14470	3050503..3050778	+	276	WP_014376926.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BLASA_RS24310	3050917..3051066	+	150	WP_014376927.1	Zn-dependent oxidoreductase	-
BLASA_RS14475	3051120..3051479	-	360	WP_041776548.1	type II toxin-antitoxin system VapC family toxin	-
BLASA_RS14480	3051506..3051772	-	267	WP_014376929.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
BLASA_RS14485	3051974..3052336	-	363	WP_014376930.1	hypothetical protein	-
BLASA_RS14490	3052333..3053469	-	1137	WP_014376931.1	ATP/GTP-binding protein	-
BLASA_RS24315	3053580..3053744	+	165	WP_083878017.1	Zn-dependent oxidoreductase	-
BLASA_RS14500	3053821..3054378	+	558	WP_014376933.1	sce7726 family protein	-
BLASA_RS14505	3054356..3055414	-	1059	WP_014376934.1	beta family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (36-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10252.76 Da
• Isoelectric Point: 8.4391

>T26137 WP_014376926.1 NC_016943:3050503-3050778 [Blastococcus saxobsidens DD2]
VTGPHTYTVVLSAAAKRAIERDLPEPVAVAVVDFLFGPLAADPYRVGKPLRFELEGYWSARRGQYRVIYSIHDDEILVRV
VRISHRADVYG

Nucleotide

• Length: 276 bp

>T26137 NC_016943:3050503-3050778 [Blastococcus saxobsidens DD2]
GTGACAGGGCCGCACACCTACACCGTCGTGCTCTCGGCAGCGGCTAAGCGGGCCATCGAGCGAGACCTGCCCGAGCCGGT
GGCCGTGGCGGTCGTCGACTTCCTGTTCGGGCCGCTCGCCGCGGACCCGTACCGGGTCGGCAAGCCGCTGCGCTTCGAAC
TCGAGGGCTACTGGTCTGCACGGAGAGGCCAGTACCGCGTGATCTATTCCATCCACGACGACGAGATCCTCGTCAGAGTG
GTACGCATCTCGCACCGCGCCGACGTCTACGGCTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9810.16 Da
• Isoelectric Point: 5.1489

>AT26137 WP_014376925.1 NC_016943:3050231-3050506 [Blastococcus saxobsidens DD2]
MSIQSLAAVKAHFSQVIDEVAGTHERVTVTKNGSPVAVILAVEDYESLMETLEILSDPRAGTEIRRAEEEMAAGKVYGEA
AVRAALAARRR

Nucleotide

• Length: 276 bp

>AT26137 NC_016943:3050231-3050506 [Blastococcus saxobsidens DD2]
ATGTCGATTCAGTCCCTGGCGGCGGTCAAGGCGCACTTCAGTCAGGTGATCGACGAGGTCGCCGGCACGCATGAGCGCGT
GACCGTCACGAAGAACGGCAGCCCGGTGGCCGTCATCCTCGCCGTCGAGGACTACGAGTCGCTGATGGAGACGTTGGAGA
TCCTGTCCGATCCCCGAGCCGGCACGGAGATCAGGCGGGCCGAGGAGGAGATGGCCGCCGGCAAGGTCTACGGCGAGGCC
GCCGTGCGCGCCGCCCTCGCCGCCCGCCGCCGGTGA

Structures

Toxin

• AlphaFold DB: H6RQ79

Antitoxin

• AlphaFold DB: H6RQ78