Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3626718..3627372 Replicon chromosome
Accession NZ_CP107452
Organism Klebsiella pneumoniae strain CRKP_14

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag OH499_RS17955 Protein ID WP_004144731.1
Coordinates 3626965..3627372 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OH499_RS17950 Protein ID WP_002916312.1
Coordinates 3626718..3626984 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH499_RS17925 3621874..3623307 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
OH499_RS17930 3623426..3624154 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OH499_RS17935 3624204..3624515 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
OH499_RS17940 3624679..3625338 + 660 WP_002916317.1 hemolysin III family protein -
OH499_RS17945 3625489..3626472 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
OH499_RS17950 3626718..3626984 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OH499_RS17955 3626965..3627372 + 408 WP_004144731.1 protein YgfX Toxin
OH499_RS17960 3627379..3627900 - 522 WP_002916308.1 flavodoxin FldB -
OH499_RS17965 3628001..3628897 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OH499_RS17970 3628920..3629633 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OH499_RS17975 3629639..3631372 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T261369 WP_004144731.1 NZ_CP107452:3626965-3627372 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT261369 WP_002916312.1 NZ_CP107452:3626718-3626984 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References