Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2186353..2186869 Replicon chromosome
Accession NZ_CP107452
Organism Klebsiella pneumoniae strain CRKP_14

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag OH499_RS10820 Protein ID WP_002886902.1
Coordinates 2186353..2186637 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OH499_RS10825 Protein ID WP_002886901.1
Coordinates 2186627..2186869 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH499_RS10795 2181837..2182145 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
OH499_RS10800 2182230..2182403 + 174 WP_002886906.1 hypothetical protein -
OH499_RS10805 2182406..2183149 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OH499_RS10810 2183506..2185644 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
OH499_RS10815 2185885..2186349 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OH499_RS10820 2186353..2186637 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OH499_RS10825 2186627..2186869 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OH499_RS10830 2186947..2188857 - 1911 WP_004152270.1 PRD domain-containing protein -
OH499_RS10835 2188880..2190034 - 1155 WP_002886900.1 lactonase family protein -
OH499_RS10840 2190100..2190840 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T261363 WP_002886902.1 NZ_CP107452:c2186637-2186353 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT261363 WP_002886901.1 NZ_CP107452:c2186869-2186627 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References