Detailed information of TA system TA026136

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2059314..2059981
• Replicon: chromosome
• Accession: NC_016943
• Organism: Blastococcus saxobsidens DD2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: H6RSW3
• Locus tag: BLASA_RS09710
• Protein ID: WP_014375949.1
• Coordinates: 2059577..2059981 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: H6RSW2
• Locus tag: BLASA_RS09705
• Protein ID: WP_014375948.1
• Coordinates: 2059314..2059580 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BLASA_RS09685	2054688..2056220	-	1533	WP_014375944.1	phytoene desaturase	-
BLASA_RS09690	2056220..2057347	-	1128	WP_014375945.1	polyprenyl synthetase family protein	-
BLASA_RS09695	2057549..2058445	+	897	WP_014375946.1	methylenetetrahydrofolate reductase [NAD(P)H]	-
BLASA_RS09700	2058417..2059070	-	654	WP_014375947.1	hypothetical protein	-
BLASA_RS09705	2059314..2059580	+	267	WP_014375948.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
BLASA_RS09710	2059577..2059981	+	405	WP_014375949.1	type II toxin-antitoxin system VapC family toxin	Toxin
BLASA_RS09715	2060007..2060225	-	219	WP_014375950.1	transporter	-
BLASA_RS09720	2060296..2061207	-	912	WP_041775702.1	hypothetical protein	-
BLASA_RS09725	2061245..2064346	-	3102	WP_014375952.1	type I restriction endonuclease subunit R	-
BLASA_RS09730	2064346..2064714	-	369	WP_014375953.1	type II toxin-antitoxin system death-on-curing family toxin	-
BLASA_RS09735	2064711..2064917	-	207	WP_014375954.1	ribbon-helix-helix protein, CopG family	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-125)

Antitoxin

• Antitoxin VapB-like (1-87)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14230.09 Da
• Isoelectric Point: 4.3454

>T26136 WP_014375949.1 NC_016943:2059577-2059981 [Blastococcus saxobsidens DD2]
VIVDASALIAIIRDEPDAEAFIDALAADTAPQMSAANYLEAAIVVDATRDPVARRRFDELLQVMSLEIVPVSVDQAHVAR
SAYRDFGKGSGHAARLNFGDCFAYALAMESGKPLLFKGDDFGHTDATPALPPVG

Nucleotide

• Length: 405 bp

>T26136 NC_016943:2059577-2059981 [Blastococcus saxobsidens DD2]
GTGATCGTCGATGCATCGGCGTTGATCGCCATCATCCGTGACGAGCCCGACGCCGAGGCGTTCATCGATGCGCTCGCCGC
GGATACCGCTCCGCAGATGTCAGCCGCCAACTATCTCGAGGCGGCCATAGTCGTCGATGCGACGCGGGACCCGGTCGCGC
GGCGACGCTTCGACGAGTTGCTGCAGGTCATGAGCCTGGAGATCGTTCCCGTGTCGGTCGACCAGGCGCATGTGGCTCGA
TCCGCCTACCGGGACTTCGGGAAAGGCAGCGGGCACGCGGCGCGGCTCAACTTCGGGGACTGCTTCGCCTATGCGCTCGC
CATGGAAAGCGGGAAGCCGCTCCTGTTCAAGGGCGACGACTTCGGCCATACGGACGCGACGCCGGCTCTTCCGCCGGTCG
GCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9364.67 Da
• Isoelectric Point: 7.2037

>AT26136 WP_014375948.1 NC_016943:2059314-2059580 [Blastococcus saxobsidens DD2]
MSLNIKNAEVEDLARRVAAVTGTSITAAVAQALREKLARLQVDSPVDTAAHRAARIRAVAKEIAPRFRGDVATVEHGDLL
YDDAGMPA

Nucleotide

• Length: 267 bp

>AT26136 NC_016943:2059314-2059580 [Blastococcus saxobsidens DD2]
ATGAGTCTCAACATCAAGAACGCCGAGGTGGAGGACCTTGCGCGTCGGGTCGCCGCCGTCACCGGGACGTCGATAACCGC
TGCCGTGGCCCAGGCCCTACGGGAGAAGCTGGCCCGCCTCCAGGTCGACTCGCCGGTGGACACGGCCGCGCACCGCGCAG
CCCGCATCAGAGCTGTGGCCAAGGAGATCGCGCCCCGATTCCGGGGAGACGTGGCGACCGTCGAGCACGGCGACCTCCTG
TACGACGACGCCGGCATGCCCGCGTGA

Structures

Toxin

• AlphaFold DB: H6RSW3

Antitoxin

• AlphaFold DB: H6RSW2