Detailed information of TA system TA026134

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF-VapB
• Location: 1303400..1303962
• Replicon: chromosome
• Accession: NC_016943
• Organism: Blastococcus saxobsidens DD2

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: BLASA_RS06210
• Protein ID: WP_014375192.1
• Coordinates: 1303400..1303729 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: H6RJJ1
• Locus tag: BLASA_RS06215
• Protein ID: WP_014375193.1
• Coordinates: 1303726..1303962 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BLASA_RS06195	1300562..1301056	+	495	WP_014375189.1	(2Fe-2S)-binding protein	-
BLASA_RS06200	1301130..1301945	+	816	WP_014375190.1	xanthine dehydrogenase family protein subunit M	-
BLASA_RS06205	1302264..1302782	+	519	WP_014375191.1	hemerythrin domain-containing protein	-
BLASA_RS06210	1303400..1303729	-	330	WP_014375192.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
BLASA_RS06215	1303726..1303962	-	237	WP_014375193.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
BLASA_RS06220	1304026..1306857	-	2832	WP_041775640.1	winged helix-turn-helix domain-containing protein	-
BLASA_RS06225	1306998..1307705	+	708	WP_014375195.1	DUF4386 domain-containing protein	-
BLASA_RS06230	1307831..1308799	+	969	Protein_1240	NAD(P)-dependent alcohol dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-106)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (9-46)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 11897.97 Da
• Isoelectric Point: 5.1640

>T26134 WP_014375192.1 NC_016943:c1303729-1303400 [Blastococcus saxobsidens DD2]
VMAMPARGEVWWCEMAEIGRRPVVVLSRDAVIPRHRRALVAPCTTTIRGLVSEVGLEPGEDPVPRCCVVNMDSVESVSVA
ILVERLGRLADTRMRQICEALAVAVDCAD

Nucleotide

• Length: 330 bp

>T26134 NC_016943:c1303729-1303400 [Blastococcus saxobsidens DD2]
GTGATGGCGATGCCCGCGCGCGGTGAGGTCTGGTGGTGCGAGATGGCCGAGATCGGGCGCCGCCCGGTCGTCGTCCTCTC
CCGCGACGCAGTGATCCCCCGACATCGGCGCGCACTCGTCGCACCATGCACCACCACGATCCGCGGCCTCGTCAGCGAAG
TCGGCCTCGAGCCCGGCGAGGACCCGGTACCCCGCTGCTGCGTGGTCAACATGGACTCGGTCGAGAGCGTCTCTGTCGCG
ATCCTCGTCGAGCGGCTCGGACGGTTGGCCGACACGCGCATGCGTCAGATCTGCGAAGCCCTCGCCGTCGCGGTCGACTG
CGCGGACTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8692.49 Da
• Isoelectric Point: 4.4964

>AT26134 WP_014375193.1 NC_016943:c1303962-1303726 [Blastococcus saxobsidens DD2]
MSRTRLSTTVDEDLLQAARRVRSGNTDAAMIDEALRALLARHRSAEVEASYTAYDEHPLDEPDEWGDLASFREAAGRS

Nucleotide

• Length: 237 bp

>AT26134 NC_016943:c1303962-1303726 [Blastococcus saxobsidens DD2]
ATGAGTAGAACACGGCTCAGCACCACCGTCGACGAGGATCTCCTCCAGGCCGCTCGACGTGTGCGATCCGGTAACACCGA
CGCCGCCATGATTGATGAAGCGCTCCGCGCGCTGCTGGCGCGCCACCGTTCGGCCGAAGTCGAGGCGAGCTACACCGCGT
ACGACGAGCACCCGCTCGACGAACCGGACGAATGGGGAGACCTGGCGTCGTTTCGCGAAGCCGCCGGACGGTCGTGA

Structures

Antitoxin

• AlphaFold DB: H6RJJ1