261295

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 48883..49619 Replicon plasmid unnamed1
Accession NZ_CP107437
Organism Klebsiella pneumoniae strain CRKP_17

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag OH508_RS27270 Protein ID WP_003026803.1
Coordinates 48883..49365 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag OH508_RS27275 Protein ID WP_003026799.1
Coordinates 49353..49619 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH508_RS27245 44045..44533 + 489 WP_004152114.1 phosphate-starvation-inducible PsiE family protein -
OH508_RS27250 44520..45482 + 963 WP_004152113.1 zinc metalloprotease HtpX -
OH508_RS27255 45659..46824 + 1166 Protein_55 IS3 family transposase -
OH508_RS27260 47033..47164 - 132 WP_004218042.1 hypothetical protein -
OH508_RS27265 47325..48671 - 1347 WP_020314316.1 ISNCY family transposase -
OH508_RS27270 48883..49365 - 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
OH508_RS27275 49353..49619 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
OH508_RS27280 49795..50049 - 255 WP_004152108.1 hypothetical protein -
OH508_RS27285 50125..50382 - 258 WP_004152107.1 hypothetical protein -
OH508_RS27290 50431..50634 - 204 WP_004152106.1 HHA domain-containing protein -
OH508_RS27295 50668..51036 - 369 WP_004152105.1 hypothetical protein -
OH508_RS27300 51080..51574 - 495 WP_004152104.1 DNA-binding protein -
OH508_RS27305 51605..52180 - 576 WP_004152103.1 hypothetical protein -
OH508_RS27310 52168..52437 - 270 WP_004152102.1 hypothetical protein -
OH508_RS27315 52795..53145 + 351 WP_004152101.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
OH508_RS27320 53195..53557 + 363 WP_004152100.1 arsenite efflux transporter metallochaperone ArsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(A) / sul1 / aadA2 / dfrA12 / aph(3')-Ia - 1..205638 205638


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T261295 WP_003026803.1 NZ_CP107437:c49365-48883 [Klebsiella pneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT261295 WP_003026799.1 NZ_CP107437:c49619-49353 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References