Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 148847..149490 Replicon plasmid unnamed1
Accession NZ_CP107433
Organism Klebsiella pneumoniae strain CRKP_18

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag OH509_RS27970 Protein ID WP_001044770.1
Coordinates 148847..149263 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag OH509_RS27975 Protein ID WP_001261282.1
Coordinates 149260..149490 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH509_RS27950 (144950) 144950..145222 - 273 Protein_190 transposase -
OH509_RS27960 (146204) 146204..147226 - 1023 WP_000361404.1 helicase UvrD -
OH509_RS27965 (147211) 147211..148773 - 1563 WP_004206609.1 AAA family ATPase -
OH509_RS27970 (148847) 148847..149263 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
OH509_RS27975 (149260) 149260..149490 - 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OH509_RS27980 (149447) 149447..149908 + 462 WP_014343465.1 hypothetical protein -
OH509_RS27985 (150069) 150069..151013 + 945 WP_011977810.1 hypothetical protein -
OH509_RS27990 (151050) 151050..151442 + 393 WP_011977811.1 hypothetical protein -
OH509_RS27995 (151500) 151500..152021 + 522 WP_013214008.1 hypothetical protein -
OH509_RS28000 (152067) 152067..152270 + 204 WP_011977813.1 hypothetical protein -
OH509_RS28005 (152300) 152300..153304 + 1005 WP_011977814.1 hypothetical protein -
OH509_RS28010 (153488) 153488..154267 + 780 WP_013214009.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid catA2 / blaKPC-2 / dfrA14 - 1..169677 169677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T261272 WP_001044770.1 NZ_CP107433:c149263-148847 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT261272 WP_001261282.1 NZ_CP107433:c149490-149260 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References