Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2088424..2088938 Replicon chromosome
Accession NC_016941
Organism Staphylococcus aureus subsp. aureus MSHR1132

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7JQI0
Locus tag SAMSHR1132_RS10175 Protein ID WP_000233591.1
Coordinates 2088424..2088633 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag SAMSHR1132_RS10180 Protein ID WP_000138932.1
Coordinates 2088645..2088938 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAMSHR1132_RS10155 2083758..2085122 - 1365 WP_000611229.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
SAMSHR1132_RS10160 2085137..2086207 - 1071 WP_000159636.1 D-alanine--D-alanine ligase -
SAMSHR1132_RS10165 2086526..2087728 + 1203 WP_001109945.1 rod shape-determining protein RodA -
SAMSHR1132_RS10170 2088158..2088295 - 138 WP_000828355.1 hypothetical protein -
SAMSHR1132_RS10175 2088424..2088633 - 210 WP_000233591.1 heavy-metal-associated domain-containing protein Toxin
SAMSHR1132_RS10180 2088645..2088938 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
SAMSHR1132_RS10185 2089106..2090590 + 1485 WP_000571570.1 cardiolipin synthase -
SAMSHR1132_RS10190 2090619..2091266 + 648 WP_001200135.1 HD domain-containing protein -
SAMSHR1132_RS10195 2091817..2092686 - 870 WP_000725805.1 membrane protein insertase YidC -
SAMSHR1132_RS10200 2092772..2093413 - 642 WP_000482953.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7827.81 Da        Isoelectric Point: 4.2681

>T26126 WP_000233591.1 NC_016941:c2088633-2088424 [Staphylococcus argenteus]
MVHQNTIYTAGIETEEQVNQLTERISNMIGVHKVNINIIDGEVVVAYETPANLNSIEKEIYDTGYKIVY

Download         Length: 210 bp

>T26126 NC_016941:c2088633-2088424 [Staphylococcus argenteus]
ATGGTACATCAAAACACAATATATACTGCAGGTATTGAAACTGAAGAACAAGTAAACCAGTTGACAGAACGTATATCAAA
CATGATAGGTGTGCATAAAGTGAATATTAATATCATTGATGGAGAAGTAGTTGTAGCATATGAAACACCCGCAAATTTAA
ATAGCATTGAAAAAGAAATTTATGATACAGGCTATAAAATTGTATATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT26126 WP_000138932.1 NC_016941:c2088938-2088645 [Staphylococcus argenteus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT26126 NC_016941:c2088938-2088645 [Staphylococcus argenteus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATTAAAACAAATCTTAAATCACGTTTAAATCGAATAGAAGGTCA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTTCTTACACAAATAAGAGCGACGCGTTCTG
CATTAAACAGTGTCGCAATAAAGTTATTAGAGCAACATATGAAAAGTTGTATTATGAATAAAGTAAATCAAGGTGCTCAA
GAAGAAGCGATGGAAGAGTTACTAGTTACTTTTCAAAAGTTGATTAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JQI0

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References