261254

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 742547..743322 Replicon chromosome
Accession NZ_CP107432
Organism Klebsiella pneumoniae strain CRKP_18

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag OH509_RS03710 Protein ID WP_004150910.1
Coordinates 742837..743322 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag OH509_RS03705 Protein ID WP_004150912.1
Coordinates 742547..742840 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH509_RS03685 737755..738357 - 603 WP_062954968.1 short chain dehydrogenase -
OH509_RS03690 738455..739366 + 912 WP_004188550.1 LysR family transcriptional regulator -
OH509_RS03695 739367..740515 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
OH509_RS03700 740526..741902 - 1377 WP_004217775.1 cystathionine beta-synthase -
OH509_RS03705 742547..742840 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
OH509_RS03710 742837..743322 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
OH509_RS03715 744026..744535 + 510 Protein_730 hypothetical protein -
OH509_RS03720 744600..745580 + 981 WP_000019445.1 IS5-like element ISKpn26 family transposase -
OH509_RS03725 745730..745819 + 90 Protein_732 hypothetical protein -
OH509_RS03730 745916..746132 + 217 Protein_733 transposase -
OH509_RS03735 746738..747610 + 873 WP_004188557.1 ParA family protein -
OH509_RS03740 747610..747993 + 384 WP_004150906.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T261254 WP_004150910.1 NZ_CP107432:742837-743322 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT261254 WP_004150912.1 NZ_CP107432:742547-742840 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References