Detailed information of TA system TA026125

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2068355..2068884
• Replicon: chromosome
• Accession: NC_016941
• Organism: Staphylococcus aureus subsp. aureus MSHR1132

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A7U7JQG1
• Locus tag: SAMSHR1132_RS10085
• Protein ID: WP_000621178.1
• Coordinates: 2068355..2068717 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: SAMSHR1132_RS10090
• Protein ID: WP_000936600.1
• Coordinates: 2068714..2068884 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAMSHR1132_RS10060	2065337..2066107	-	771	WP_001041104.1	RNA polymerase sigma factor SigB	-
SAMSHR1132_RS10065	2066082..2066561	-	480	WP_001190826.1	anti-sigma B factor RsbW	-
SAMSHR1132_RS10070	2066563..2066889	-	327	WP_001052491.1	anti-sigma factor antagonist	-
SAMSHR1132_RS10075	2067006..2068007	-	1002	WP_000390825.1	PP2C family protein-serine/threonine phosphatase	-
SAMSHR1132_RS10085	2068355..2068717	-	363	WP_000621178.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
SAMSHR1132_RS10090	2068714..2068884	-	171	WP_000936600.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
SAMSHR1132_RS10095	2068969..2070117	-	1149	WP_001281137.1	alanine racemase	-
SAMSHR1132_RS10100	2070187..2070546	-	360	WP_000581192.1	holo-ACP synthase	-
SAMSHR1132_RS10105	2070550..2071053	-	504	WP_000020263.1	PH domain-containing protein	-
SAMSHR1132_RS10110	2071040..2072623	-	1584	WP_000042905.1	PH domain-containing protein	-
SAMSHR1132_RS10115	2072616..2073095	-	480	WP_000070747.1	PH domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13502.79 Da
• Isoelectric Point: 10.2892

>T26125 WP_000621178.1 NC_016941:c2068717-2068355 [Staphylococcus argenteus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDNKMKEVDNALMISLGLNTMAHQKN

Nucleotide

• Length: 363 bp

>T26125 NC_016941:c2068717-2068355 [Staphylococcus argenteus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTTGT
CATTATTCAAAATGACACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCCA
AAATACCGACCCATGTAGAGATTGAAAAGAAAAAATATAAACTGGATAAAGATTCAGTTATATTATTAGAACAAATTCGG
ACACTTGATAAAAAACGTTTAAAAGAAAAACTGACGTACTTATCAGACAACAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTAAACACAATGGCTCATCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6261.82 Da
• Isoelectric Point: 3.8305

>AT26125 WP_000936600.1 NC_016941:c2068884-2068714 [Staphylococcus argenteus]
MLPFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT26125 NC_016941:c2068884-2068714 [Staphylococcus argenteus]
ATGTTACCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCAATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Toxin

• AlphaFold DB: A0A7U7JQG1