261230

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1851145..1851799 Replicon chromosome
Accession NZ_CP107426
Organism Klebsiella pneumoniae strain CRKP_19

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag OH521_RS09090 Protein ID WP_004144731.1
Coordinates 1851145..1851552 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OH521_RS09095 Protein ID WP_002916312.1
Coordinates 1851533..1851799 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH521_RS09070 1847145..1848878 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
OH521_RS09075 1848884..1849597 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OH521_RS09080 1849620..1850516 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OH521_RS09085 1850617..1851138 + 522 WP_002916308.1 flavodoxin FldB -
OH521_RS09090 1851145..1851552 - 408 WP_004144731.1 protein YgfX Toxin
OH521_RS09095 1851533..1851799 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OH521_RS09100 1852045..1853028 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
OH521_RS09105 1853179..1853838 - 660 WP_002916317.1 hemolysin III family protein -
OH521_RS09110 1854002..1854313 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
OH521_RS09115 1854363..1855091 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OH521_RS09120 1855210..1856643 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T261230 WP_004144731.1 NZ_CP107426:c1851552-1851145 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT261230 WP_002916312.1 NZ_CP107426:c1851799-1851533 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References