Detailed information of TA system TA026122

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1875438..1876225
• Replicon: chromosome
• Accession: NC_016941
• Organism: Staphylococcus aureus subsp. aureus MSHR1132

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: A0A7U7PZK3
• Locus tag: SAMSHR1132_RS08900
• Protein ID: WP_000031103.1
• Coordinates: 1875438..1875593 (-)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: SAMSHR1132_RS08905
• Protein ID: WP_001251215.1
• Coordinates: 1875626..1876225 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAMSHR1132_RS08880	1870629..1871741	-	1113	WP_000436094.1	GAF domain-containing sensor histidine kinase	-
SAMSHR1132_RS08885	1871903..1872724	+	822	WP_000669386.1	RluA family pseudouridine synthase	-
SAMSHR1132_RS08890	1873018..1874403	-	1386	WP_000116241.1	class II fumarate hydratase	-
SAMSHR1132_RS08895	1874574..1874975	-	402	WP_000901017.1	hypothetical protein	-
SAMSHR1132_RS08900	1875438..1875593	-	156	WP_000031103.1	hypothetical protein	Toxin
SAMSHR1132_RS08905	1875626..1876225	-	600	WP_001251215.1	glucosamine-6-phosphate isomerase	Antitoxin
SAMSHR1132_RS08910	1876384..1876854	-	471	WP_000181399.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
SAMSHR1132_RS08915	1876856..1877986	-	1131	WP_000379994.1	tRNA epoxyqueuosine(34) reductase QueG	-
SAMSHR1132_RS08920	1878137..1878859	-	723	WP_000590808.1	amino acid ABC transporter ATP-binding protein	-
SAMSHR1132_RS08925	1878852..1880309	-	1458	WP_000649887.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 6019.42 Da
• Isoelectric Point: 4.1469

>T26122 WP_000031103.1 NC_016941:c1875593-1875438 [Staphylococcus argenteus]
MSKDKDAKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKSTDEKNSH

Nucleotide

• Length: 156 bp

>T26122 NC_016941:c1875593-1875438 [Staphylococcus argenteus]
ATGTCTAAAGATAAAGATGCAAAATTAAATTATCACGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAGATGGAACAAATTTCAGATCAAAATGATCAAGAGAAGAGTACTGATGAAAAGAATAGCCATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22452.60 Da
• Isoelectric Point: 5.3935

>AT26122 WP_001251215.1 NC_016941:c1876225-1875626 [Staphylococcus argenteus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPILDELKKNVEKHAVDFSQINILDYDNKKSYFEALGV
PASQIYPIAFEKDAIEFISDKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKKEVVEKLYQENGK
TSFEPSDLKSHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT26122 NC_016941:c1876225-1875626 [Staphylococcus argenteus]
ATGGCAATGAACTTTAAAGTATTTGACAACAGTCAACTTGTAGCAGAATATGCTGCAGATATTATTAGAAAACAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTGGATACAGACCAAGCACCAATATTAGATGAACTAAAGAAAAACGTTG
AGAAACACGCTGTTGATTTTAGTCAAATAAATATTTTAGATTATGACAATAAAAAATCTTATTTTGAAGCATTAGGCGTG
CCAGCAAGTCAAATCTATCCAATTGCGTTTGAAAAAGATGCTATTGAATTTATCTCTGACAAAATTAAAACTAAAGAAAA
TAAAGGCAAACTAACATTACAAGTTGTTTCTATTGATGAGCAAGGAAAATTAAATGTTAGTATCCGCCAAGGTTTAATGG
AAGCGAGAGAAATATTTTTAGTTGTGACAGGTGCTAATAAAAAGGAAGTTGTTGAAAAATTATACCAAGAAAATGGTAAA
ACAAGTTTCGAACCATCTGACTTAAAATCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTCAAAGCTTACTTTACATCTCGCTTTGCTTAA

Structures

Toxin

• AlphaFold DB: A0A7U7PZK3