Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2159891..2160407 Replicon chromosome
Accession NZ_CP107422
Organism Klebsiella pneumoniae strain CRKP_20

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag OH530_RS10685 Protein ID WP_002886902.1
Coordinates 2159891..2160175 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OH530_RS10690 Protein ID WP_002886901.1
Coordinates 2160165..2160407 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH530_RS10660 2155375..2155683 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
OH530_RS10665 2155768..2155941 + 174 WP_002886906.1 hypothetical protein -
OH530_RS10670 2155944..2156687 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OH530_RS10675 2157044..2159182 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
OH530_RS10680 2159423..2159887 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OH530_RS10685 2159891..2160175 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OH530_RS10690 2160165..2160407 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OH530_RS10695 2160485..2162395 - 1911 WP_004152270.1 PRD domain-containing protein -
OH530_RS10700 2162418..2163572 - 1155 WP_002886900.1 lactonase family protein -
OH530_RS10705 2163638..2164378 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T261208 WP_002886902.1 NZ_CP107422:c2160175-2159891 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT261208 WP_002886901.1 NZ_CP107422:c2160407-2160165 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References