261206

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1444620..1445239 Replicon chromosome
Accession NZ_CP107422
Organism Klebsiella pneumoniae strain CRKP_20

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag OH530_RS07255 Protein ID WP_002892050.1
Coordinates 1445021..1445239 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag OH530_RS07250 Protein ID WP_002892066.1
Coordinates 1444620..1444994 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH530_RS07240 1439772..1440965 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OH530_RS07245 1440988..1444134 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
OH530_RS07250 1444620..1444994 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
OH530_RS07255 1445021..1445239 + 219 WP_002892050.1 HHA domain-containing protein Toxin
OH530_RS07260 1445398..1445964 + 567 WP_002892030.1 maltose O-acetyltransferase -
OH530_RS07265 1445936..1446076 - 141 WP_004147370.1 hypothetical protein -
OH530_RS07270 1446097..1446567 + 471 WP_002892026.1 YlaC family protein -
OH530_RS07275 1446542..1447993 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
OH530_RS07280 1448094..1448792 + 699 WP_002892021.1 GNAT family protein -
OH530_RS07285 1448789..1448929 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
OH530_RS07290 1448929..1449192 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T261206 WP_002892050.1 NZ_CP107422:1445021-1445239 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT261206 WP_002892066.1 NZ_CP107422:1444620-1444994 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References