261193

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 67487..68130 Replicon plasmid unnamed1
Accession NZ_CP107418
Organism Klebsiella pneumoniae strain CRKP_21

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag OH498_RS27440 Protein ID WP_001044770.1
Coordinates 67714..68130 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag OH498_RS27435 Protein ID WP_001261282.1
Coordinates 67487..67717 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH498_RS27400 (62710) 62710..63489 - 780 WP_013214009.1 site-specific integrase -
OH498_RS27405 (63673) 63673..64677 - 1005 WP_011977814.1 hypothetical protein -
OH498_RS27410 (64707) 64707..64910 - 204 WP_011977813.1 hypothetical protein -
OH498_RS27415 (64956) 64956..65477 - 522 WP_013214008.1 hypothetical protein -
OH498_RS27420 (65535) 65535..65927 - 393 WP_011977811.1 hypothetical protein -
OH498_RS27425 (65964) 65964..66908 - 945 WP_011977810.1 hypothetical protein -
OH498_RS27430 (67069) 67069..67530 - 462 WP_014343465.1 hypothetical protein -
OH498_RS27435 (67487) 67487..67717 + 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OH498_RS27440 (67714) 67714..68130 + 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
OH498_RS27445 (68204) 68204..69766 + 1563 WP_004206609.1 AAA family ATPase -
OH498_RS27450 (69751) 69751..70773 + 1023 WP_000361404.1 helicase UvrD -
OH498_RS27455 (71029) 71029..71726 + 698 WP_223174630.1 IS1 family transposase -
OH498_RS27460 (71755) 71755..72027 + 273 Protein_101 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaKPC-2 / blaCTX-M-65 / blaTEM-1B / rmtB - 1..210034 210034


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T261193 WP_001044770.1 NZ_CP107418:67714-68130 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT261193 WP_001261282.1 NZ_CP107418:67487-67717 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References