Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 845629..846106 Replicon chromosome
Accession NC_016941
Organism Staphylococcus aureus subsp. aureus MSHR1132

Toxin (Protein)


Gene name TsaT Uniprot ID A0A7U7JTG2
Locus tag SAMSHR1132_RS03915 Protein ID WP_000172413.1
Coordinates 845629..845817 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID A0A7U7JTE3
Locus tag SAMSHR1132_RS03920 Protein ID WP_000790107.1
Coordinates 845846..846106 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAMSHR1132_RS03880 841241..841750 + 510 WP_000727672.1 hypothetical protein -
SAMSHR1132_RS03885 842093..842761 + 669 WP_000141443.1 thermonuclease family protein -
SAMSHR1132_RS03890 843125..843325 + 201 WP_001059082.1 cold-shock protein -
SAMSHR1132_RS03895 843938..844150 - 213 WP_001007088.1 hypothetical protein -
SAMSHR1132_RS03900 844211..844495 - 285 WP_001004396.1 hypothetical protein -
SAMSHR1132_RS03905 844584..845153 - 570 WP_000668727.1 hypothetical protein -
SAMSHR1132_RS03915 845629..845817 - 189 WP_000172413.1 hypothetical protein Toxin
SAMSHR1132_RS03920 845846..846106 - 261 WP_000790107.1 hypothetical protein Antitoxin
SAMSHR1132_RS03925 846446..846649 + 204 WP_000145167.1 sterile alpha motif-like domain-containing protein -
SAMSHR1132_RS03930 846646..846882 - 237 WP_000368686.1 hypothetical protein -
SAMSHR1132_RS03935 847107..847688 + 582 WP_001140698.1 phosphoglycerate mutase family protein -
SAMSHR1132_RS03940 847755..848372 - 618 WP_000947286.1 LysE/ArgO family amino acid transporter -
SAMSHR1132_RS03945 848538..849029 - 492 WP_000695603.1 GNAT family N-acetyltransferase -
SAMSHR1132_RS03950 849436..849858 - 423 WP_001007646.1 organic hydroperoxide resistance protein -
SAMSHR1132_RS03955 850007..850726 + 720 WP_000648667.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(6-58)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7192.89 Da        Isoelectric Point: 9.9971

>T26118 WP_000172413.1 NC_016941:c845817-845629 [Staphylococcus argenteus]
MTLHFAILFWLALIFIVAGTFIFVLMKKTAKESKKESYLSFAVIFYIFGFAMLIYTLIFGIL

Download         Length: 189 bp

>T26118 NC_016941:c845817-845629 [Staphylococcus argenteus]
ATGACTTTACATTTTGCAATTTTATTTTGGCTAGCATTAATTTTTATCGTTGCTGGTACATTTATATTTGTCTTAATGAA
AAAAACTGCTAAAGAATCTAAAAAAGAATCTTATTTAAGCTTCGCTGTTATTTTCTATATTTTTGGATTCGCAATGCTAA
TTTATACATTAATATTTGGAATTCTTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10089.30 Da        Isoelectric Point: 4.1927

>AT26118 WP_000790107.1 NC_016941:c846106-845846 [Staphylococcus argenteus]
MKNIQLNAINLVITIIFAIFNIMITYNKDLDDLCWLLPGIIICGSILIVSFTIAMITKFWLSEILFFINIVLVLYYIYPI
FYDFIN

Download         Length: 261 bp

>AT26118 NC_016941:c846106-845846 [Staphylococcus argenteus]
ATGAAAAACATTCAATTAAATGCTATAAATTTAGTTATAACAATCATATTTGCTATCTTTAACATTATGATTACATATAA
CAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGCATTATCATTTGCGGTTCGATACTCATTGTATCGTTTACCATTG
CAATGATTACTAAATTCTGGTTAAGTGAAATATTATTTTTTATTAACATCGTGCTCGTTCTTTATTATATTTATCCAATT
TTTTATGATTTCATTAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JTG2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7JTE3

References