Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 4057..4637 Replicon plasmid unnamed3
Accession NZ_CP107415
Organism Klebsiella pneumoniae strain CRKP_22

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag OH525_RS28750 Protein ID WP_071177730.1
Coordinates 4057..4371 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag OH525_RS28755 Protein ID WP_000093040.1
Coordinates 4359..4637 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH525_RS28725 1..1965 + 1965 WP_071177727.1 TraM recognition domain-containing protein -
OH525_RS28730 1965..2696 + 732 WP_071177728.1 MobC family replication-relaxation protein -
OH525_RS28735 2703..3233 + 531 WP_071177729.1 hypothetical protein -
OH525_RS28740 3260..3439 - 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
OH525_RS28745 3465..3893 - 429 WP_001140599.1 hypothetical protein -
OH525_RS28750 4057..4371 - 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OH525_RS28755 4359..4637 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
OH525_RS28760 4812..5177 - 366 WP_072354022.1 TonB family protein -
OH525_RS28765 5174..5545 - 372 WP_001237044.1 cell envelope integrity protein TolA -
OH525_RS28770 5819..6064 - 246 WP_032440458.1 hypothetical protein -
OH525_RS28775 6391..8076 + 1686 WP_032440457.1 colicin-like bacteriocin tRNase domain-containing protein -
OH525_RS28780 8086..8343 + 258 WP_032440455.1 colicin E3-like toxin immunity protein -
OH525_RS28785 8428..8577 + 150 WP_032440454.1 colicin release lysis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10060 10060


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T261178 WP_071177730.1 NZ_CP107415:c4371-4057 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT261178 WP_000093040.1 NZ_CP107415:c4637-4359 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References