26117

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 668557..669218 Replicon chromosome
Accession NC_016935
Organism Paenibacillus mucilaginosus 3016

Toxin (Protein)


Gene name pemK Uniprot ID A0A916K9N6
Locus tag PM3016_RS03000 Protein ID WP_014649298.1
Coordinates 668868..669218 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag PM3016_RS02995 Protein ID WP_013914410.1
Coordinates 668557..668862 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PM3016_RS02975 664037..664750 + 714 WP_148279655.1 glycosyltransferase family 2 protein -
PM3016_RS02980 664753..665094 + 342 WP_041619021.1 DUF2304 domain-containing protein -
PM3016_RS36985 665087..665422 + 336 WP_081484299.1 EamA family transporter -
PM3016_RS02985 665554..666954 + 1401 WP_014368381.1 outer membrane lipoprotein-sorting protein -
PM3016_RS02990 667153..668337 + 1185 WP_014368382.1 alanine racemase -
PM3016_RS02995 668557..668862 + 306 WP_013914410.1 CopG family ribbon-helix-helix protein Antitoxin
PM3016_RS03000 668868..669218 + 351 WP_014649298.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PM3016_RS03005 669349..671529 + 2181 WP_187297994.1 RNA-binding transcriptional accessory protein -
PM3016_RS37810 671699..671851 - 153 WP_143768091.1 cortex morphogenetic protein CmpA -
PM3016_RS03010 671949..672317 - 369 WP_013914414.1 hypothetical protein -
PM3016_RS03015 672473..672949 + 477 WP_014368385.1 SprT family protein -
PM3016_RS03040 673780..674199 + 420 WP_013914416.1 pyridoxamine 5'-phosphate oxidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(17-54)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12890.84 Da        Isoelectric Point: 4.8837

>T26117 WP_014649298.1 NC_016935:668868-669218 [Paenibacillus mucilaginosus 3016]
MIVKRGDVFFADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAEAHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEETMRKVDDALQISVGLIEF

Download         Length: 351 bp

>T26117 NC_016935:668868-669218 [Paenibacillus mucilaginosus 3016]
TTGATTGTCAAACGTGGCGATGTCTTTTTCGCAGATCTGTCCCCCGTGGTGGGGTCCGAGCAGGGCGGTATCCGGCCCGT
TCTGATCATTCAGAATGATATCGGTAACAGATTCAGTCCCACGGTCATCGTGGCGGCCATCACGGCCCAGATTCAGAAAG
CCAAGCTGCCCACGCATGTGGAGATCGACGCGGAAGCGCACGGTTTTGACAGGGATTCCGTCATCCTTCTGGAGCAGATC
CGCACCATAGACAAACAGCGTCTTACAGATAAGATTACCCATCTGGATGAAGAAACCATGCGCAAGGTCGATGACGCCCT
TCAGATAAGTGTCGGACTGATTGAATTTTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11867.61 Da        Isoelectric Point: 6.4868

>AT26117 WP_013914410.1 NC_016935:668557-668862 [Paenibacillus mucilaginosus 3016]
MFLGVHDQVANVQNTKRIMISLPDHLLQEVDYLVEKENSNRSEFIRQAMKLYLTERKKRHLRETMQRGYMEMAKINLHMA
SEAFQAEEEADTTLDRLVSGV

Download         Length: 306 bp

>AT26117 NC_016935:668557-668862 [Paenibacillus mucilaginosus 3016]
ATGTTTTTGGGGGTGCATGATCAGGTGGCCAATGTGCAGAACACGAAACGAATTATGATCAGTTTACCGGACCATTTGCT
GCAGGAGGTGGACTATCTCGTGGAAAAGGAAAATTCCAATCGGAGCGAGTTCATCCGACAAGCGATGAAGCTTTATTTGA
CTGAGCGCAAGAAGCGGCATTTGCGTGAAACCATGCAGCGTGGATACATGGAAATGGCCAAGATCAACCTTCATATGGCC
TCGGAAGCATTCCAAGCGGAGGAAGAGGCGGATACCACGCTTGACCGTCTGGTGAGCGGGGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References