Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 125412..126055 Replicon plasmid unnamed1
Accession NZ_CP107413
Organism Klebsiella pneumoniae strain CRKP_22

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag OH525_RS27335 Protein ID WP_014386165.1
Coordinates 125412..125828 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag OH525_RS27340 Protein ID WP_032408893.1
Coordinates 125825..126055 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH525_RS27310 122032..122463 + 432 WP_014386161.1 conjugation system SOS inhibitor PsiB -
OH525_RS27315 122460..123188 + 729 WP_014386162.1 plasmid SOS inhibition protein A -
OH525_RS27320 123185..123511 + 327 WP_001568059.1 hypothetical protein -
OH525_RS27325 123567..123941 + 375 WP_032408891.1 hypothetical protein -
OH525_RS27330 124121..125089 - 969 WP_077895871.1 IS5-like element IS903B family transposase -
OH525_RS27335 125412..125828 - 417 WP_014386165.1 PIN domain-containing protein Toxin
OH525_RS27340 125825..126055 - 231 WP_032408893.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OH525_RS27345 126375..126809 + 435 WP_000103648.1 RidA family protein -
OH525_RS27350 126814..127488 + 675 WP_014386166.1 DUF1028 domain-containing protein -
OH525_RS27355 127504..128661 + 1158 WP_032408895.1 acetylornithine deacetylase -
OH525_RS27360 128832..129980 + 1149 WP_014386168.1 ABC transporter ATP-binding protein -
OH525_RS27365 129999..130982 + 984 WP_001471744.1 NAD(P)H-quinone oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(A) / sul1 / qacE / aadA2 / dfrA12 / aph(3')-Ia - 1..205642 205642
- flank IS/Tn - - 124121..125089 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15127.44 Da        Isoelectric Point: 7.8841

>T261169 WP_014386165.1 NZ_CP107413:c125828-125412 [Klebsiella pneumoniae]
MTKTYMLDTNICSYIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGAIGKRASPRHVQLVDAFCARLDAILAWDRA
AVDATTEVKATLAAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVAGLTFEDWVQ

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8854.89 Da        Isoelectric Point: 4.5112

>AT261169 WP_032408893.1 NZ_CP107413:c126055-125825 [Klebsiella pneumoniae]
MRTVSVFRNGNNRAIRLPRDLDFDGVNELEIIREGDTLILRPVKPSWSSFRQEEKADADFMAERENVVSDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References