Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5003638..5005319 Replicon chromosome
Accession NZ_CP107412
Organism Klebsiella pneumoniae strain CRKP_22

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag OH525_RS24770 Protein ID WP_002885155.1
Coordinates 5003638..5004555 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag OH525_RS24775 Protein ID WP_004151732.1
Coordinates 5004561..5005319 (-) Length 253 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH525_RS24750 4998944..5000464 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
OH525_RS24755 5000461..5001459 + 999 WP_002885172.1 ribose ABC transporter permease -
OH525_RS24760 5001490..5002431 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
OH525_RS24765 5002506..5003513 + 1008 WP_004151731.1 carbohydrate kinase family protein -
OH525_RS24770 5003638..5004555 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
OH525_RS24775 5004561..5005319 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
OH525_RS24780 5005405..5006133 - 729 WP_002885152.1 response regulator transcription factor -
OH525_RS24785 5006406..5008553 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
OH525_RS24790 5008783..5009469 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T261166 WP_002885155.1 NZ_CP107412:c5004555-5003638 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp


Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT261166 WP_004151732.1 NZ_CP107412:c5005319-5004561 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References