Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2755036..2756624 Replicon chromosome
Accession NZ_CP107412
Organism Klebsiella pneumoniae strain CRKP_22

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag OH525_RS13665 Protein ID WP_004199851.1
Coordinates 2755036..2756358 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag OH525_RS13670 Protein ID WP_002904790.1
Coordinates 2756358..2756624 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH525_RS13650 2750101..2752602 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
OH525_RS13655 2752590..2753594 + 1005 WP_004199852.1 fimbrial protein -
OH525_RS13660 2753727..2755019 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OH525_RS13665 2755036..2756358 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
OH525_RS13670 2756358..2756624 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OH525_RS13675 2756890..2757216 - 327 WP_002904788.1 hydroxyisourate hydrolase -
OH525_RS13680 2757213..2757713 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OH525_RS13685 2757691..2759070 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
OH525_RS13690 2759416..2760570 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OH525_RS13695 2760551..2761474 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T261162 WP_004199851.1 NZ_CP107412:c2756358-2755036 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT261162 WP_002904790.1 NZ_CP107412:c2756624-2756358 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References