Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5462070..5462695 Replicon chromosome
Accession NZ_CP107408
Organism Klebsiella pneumoniae strain CRKP_24

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OH533_RS27110 Protein ID WP_002882817.1
Coordinates 5462070..5462453 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OH533_RS27115 Protein ID WP_004150355.1
Coordinates 5462453..5462695 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH533_RS27095 5459436..5460338 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OH533_RS27100 5460335..5460970 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OH533_RS27105 5460967..5461896 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OH533_RS27110 5462070..5462453 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OH533_RS27115 5462453..5462695 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OH533_RS27120 5462900..5463817 + 918 WP_002882812.1 alpha/beta hydrolase -
OH533_RS27125 5463831..5464772 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OH533_RS27130 5464817..5465254 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OH533_RS27135 5465251..5466111 - 861 WP_002882807.1 virulence factor BrkB family protein -
OH533_RS27140 5466105..5466704 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T261145 WP_002882817.1 NZ_CP107408:c5462453-5462070 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT261145 WP_004150355.1 NZ_CP107408:c5462695-5462453 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References