Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4231316..4231935 Replicon chromosome
Accession NZ_CP107408
Organism Klebsiella pneumoniae strain CRKP_24

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag OH533_RS21145 Protein ID WP_002892050.1
Coordinates 4231717..4231935 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag OH533_RS21140 Protein ID WP_002892066.1
Coordinates 4231316..4231690 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH533_RS21130 4226468..4227661 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OH533_RS21135 4227684..4230830 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
OH533_RS21140 4231316..4231690 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
OH533_RS21145 4231717..4231935 + 219 WP_002892050.1 HHA domain-containing protein Toxin
OH533_RS21150 4232094..4232660 + 567 WP_002892030.1 maltose O-acetyltransferase -
OH533_RS21155 4232632..4232772 - 141 WP_004147370.1 hypothetical protein -
OH533_RS21160 4232793..4233263 + 471 WP_002892026.1 YlaC family protein -
OH533_RS21165 4233238..4234689 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
OH533_RS21170 4234790..4235488 + 699 WP_002892021.1 GNAT family protein -
OH533_RS21175 4235485..4235625 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
OH533_RS21180 4235625..4235888 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T261141 WP_002892050.1 NZ_CP107408:4231717-4231935 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT261141 WP_002892066.1 NZ_CP107408:4231316-4231690 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References