26112

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2115962..2116476 Replicon chromosome
Accession NC_016928
Organism Staphylococcus aureus subsp. aureus M013

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag M013TW_RS10550 Protein ID WP_000581792.1
Coordinates 2115962..2116171 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag M013TW_RS10555 Protein ID WP_000138934.1
Coordinates 2116183..2116476 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M013TW_RS10530 2111470..2112828 - 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
M013TW_RS10535 2112843..2113913 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
M013TW_RS10540 2114231..2115433 + 1203 WP_001109939.1 rod shape-determining protein RodA -
M013TW_RS10545 2115697..2115834 - 138 WP_000828354.1 hypothetical protein -
M013TW_RS10550 2115962..2116171 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
M013TW_RS10555 2116183..2116476 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
M013TW_RS10560 2116642..2118126 + 1485 WP_000571549.1 cardiolipin synthase -
M013TW_RS10565 2118154..2118801 + 648 WP_001187610.1 HD domain-containing protein -
M013TW_RS10590 2119616..2120488 - 873 WP_000725802.1 membrane protein insertase YidC -
M013TW_RS10595 2120574..2121215 - 642 WP_000483147.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T26112 WP_000581792.1 NC_016928:c2116171-2115962 [Staphylococcus aureus subsp. aureus M013]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T26112 NC_016928:c2116171-2115962 [Staphylococcus aureus subsp. aureus M013]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCGTATGAAACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT26112 WP_000138934.1 NC_016928:c2116476-2116183 [Staphylococcus aureus subsp. aureus M013]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT26112 NC_016928:c2116476-2116183 [Staphylococcus aureus subsp. aureus M013]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References