Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1460690..1461309 Replicon chromosome
Accession NZ_CP107403
Organism Klebsiella pneumoniae strain CRKP_25

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag OH516_RS07325 Protein ID WP_002892050.1
Coordinates 1461091..1461309 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag OH516_RS07320 Protein ID WP_002892066.1
Coordinates 1460690..1461064 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH516_RS07310 1455842..1457035 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OH516_RS07315 1457058..1460204 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
OH516_RS07320 1460690..1461064 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
OH516_RS07325 1461091..1461309 + 219 WP_002892050.1 HHA domain-containing protein Toxin
OH516_RS07330 1461468..1462034 + 567 WP_002892030.1 maltose O-acetyltransferase -
OH516_RS07335 1462006..1462146 - 141 WP_004147370.1 hypothetical protein -
OH516_RS07340 1462167..1462637 + 471 WP_002892026.1 YlaC family protein -
OH516_RS07345 1462612..1464063 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
OH516_RS07350 1464164..1464862 + 699 WP_002892021.1 GNAT family protein -
OH516_RS07355 1464859..1464999 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
OH516_RS07360 1464999..1465262 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T261111 WP_002892050.1 NZ_CP107403:1461091-1461309 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT261111 WP_002892066.1 NZ_CP107403:1460690-1461064 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References