Detailed information of TA system TA026111

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2096222..2096751
• Replicon: chromosome
• Accession: NC_016928
• Organism: Staphylococcus aureus subsp. aureus M013

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: M013TW_RS10460
• Protein ID: WP_000621175.1
• Coordinates: 2096222..2096584 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: M013TW_RS10465
• Protein ID: WP_000948331.1
• Coordinates: 2096581..2096751 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M013TW_RS10440	2093200..2093970	-	771	WP_001041107.1	RNA polymerase sigma factor SigB	-
M013TW_RS10445	2093945..2094424	-	480	WP_001190825.1	anti-sigma B factor RsbW	-
M013TW_RS10450	2094426..2094752	-	327	WP_001052491.1	anti-sigma factor antagonist	-
M013TW_RS10455	2094871..2095872	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
M013TW_RS10460	2096222..2096584	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
M013TW_RS10465	2096581..2096751	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
M013TW_RS10470	2096836..2097984	-	1149	WP_001280702.1	alanine racemase	-
M013TW_RS10475	2098050..2098409	-	360	WP_000581194.1	holo-ACP synthase	-
M013TW_RS10480	2098413..2098904	-	492	WP_001205915.1	PH domain-containing protein	-
M013TW_RS10485	2098891..2100474	-	1584	WP_001294642.1	PH domain-containing protein	-
M013TW_RS10490	2100467..2100946	-	480	WP_001287083.1	hypothetical protein	-
M013TW_RS10495	2101155..2101715	-	561	WP_001092405.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T26111 WP_000621175.1 NC_016928:c2096584-2096222 [Staphylococcus aureus subsp. aureus M013]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T26111 NC_016928:c2096584-2096222 [Staphylococcus aureus subsp. aureus M013]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT26111 WP_000948331.1 NC_016928:c2096751-2096581 [Staphylococcus aureus subsp. aureus M013]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT26111 NC_016928:c2096751-2096581 [Staphylococcus aureus subsp. aureus M013]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1