26110

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1943943..1944719 Replicon chromosome
Accession NC_016928
Organism Staphylococcus aureus subsp. aureus M013

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag M013TW_RS09565 Protein ID WP_000031108.1
Coordinates 1943943..1944095 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A6B1RP77
Locus tag M013TW_RS09570 Protein ID WP_001251218.1
Coordinates 1944120..1944719 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M013TW_RS09545 1940018..1940839 + 822 WP_000669384.1 RluA family pseudouridine synthase -
M013TW_RS09550 1941304..1942689 - 1386 WP_000116233.1 class II fumarate hydratase -
M013TW_RS09555 1942885..1943280 - 396 WP_000901022.1 hypothetical protein -
M013TW_RS09565 1943943..1944095 - 153 WP_000031108.1 hypothetical protein Toxin
M013TW_RS09570 1944120..1944719 - 600 WP_001251218.1 glucosamine-6-phosphate isomerase Antitoxin
M013TW_RS09575 1944878..1945348 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
M013TW_RS09580 1945353..1946480 - 1128 WP_000379977.1 tRNA epoxyqueuosine(34) reductase QueG -
M013TW_RS09585 1946631..1947353 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
M013TW_RS09590 1947346..1948803 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T26110 WP_000031108.1 NC_016928:c1944095-1943943 [Staphylococcus aureus subsp. aureus M013]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T26110 NC_016928:c1944095-1943943 [Staphylococcus aureus subsp. aureus M013]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT26110 WP_001251218.1 NC_016928:c1944719-1944120 [Staphylococcus aureus subsp. aureus M013]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFIVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT26110 NC_016928:c1944719-1944120 [Staphylococcus aureus subsp. aureus M013]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAGCATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATTGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCATAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A6B1RP77

References