Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 91010..91653 Replicon plasmid unnamed1
Accession NZ_CP107395
Organism Klebsiella pneumoniae strain CRKP_27

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag OH529_RS27430 Protein ID WP_001044770.1
Coordinates 91010..91426 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag OH529_RS27435 Protein ID WP_001261282.1
Coordinates 91423..91653 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH529_RS27410 (87113) 87113..87385 - 273 Protein_108 transposase -
OH529_RS27420 (88367) 88367..89389 - 1023 WP_000361404.1 helicase UvrD -
OH529_RS27425 (89374) 89374..90936 - 1563 WP_004206609.1 AAA family ATPase -
OH529_RS27430 (91010) 91010..91426 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
OH529_RS27435 (91423) 91423..91653 - 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OH529_RS27440 (91610) 91610..92071 + 462 WP_014343465.1 hypothetical protein -
OH529_RS27445 (92232) 92232..93176 + 945 WP_011977810.1 hypothetical protein -
OH529_RS27450 (93213) 93213..93605 + 393 WP_011977811.1 hypothetical protein -
OH529_RS27455 (93663) 93663..94184 + 522 WP_013214008.1 hypothetical protein -
OH529_RS27460 (94230) 94230..94433 + 204 WP_011977813.1 hypothetical protein -
OH529_RS27465 (94463) 94463..95467 + 1005 WP_011977814.1 hypothetical protein -
OH529_RS27470 (95651) 95651..96430 + 780 WP_013214009.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid rmtB / blaTEM-1B / blaCTX-M-65 / blaKPC-2 - 1..154664 154664


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T261082 WP_001044770.1 NZ_CP107395:c91426-91010 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT261082 WP_001261282.1 NZ_CP107395:c91653-91423 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References