Detailed information of TA system TA026108

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 876495..877027
• Replicon: chromosome
• Accession: NC_016928
• Organism: Staphylococcus aureus subsp. aureus M013

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: M013TW_RS04225
• Protein ID: WP_001103942.1
• Coordinates: 876707..877027 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: M013TW_RS04220
• Protein ID: WP_001058486.1
• Coordinates: 876495..876704 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M013TW_RS04175	871515..872735	-	1221	WP_000266157.1	site-specific integrase	-
M013TW_RS04180	872823..873551	-	729	WP_000733774.1	staphylococcal enterotoxin type K	-
M013TW_RS04185	873575..874303	-	729	WP_001033318.1	staphylococcal enterotoxin type Q	-
M013TW_RS04190	874373..874804	-	432	WP_001228759.1	hypothetical protein	-
M013TW_RS04195	874821..875279	-	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
M013TW_RS04200	875291..875623	-	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
M013TW_RS04205	875816..876079	+	264	WP_000243851.1	helix-turn-helix domain-containing protein	-
M013TW_RS04210	876072..876344	+	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
M013TW_RS04215	876356..876502	+	147	WP_000784875.1	hypothetical protein	-
M013TW_RS04220	876495..876704	+	210	WP_001058486.1	hypothetical protein	Antitoxin
M013TW_RS04225	876707..877027	+	321	WP_001103942.1	DUF1474 family protein	Toxin
M013TW_RS04230	877091..877960	+	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
M013TW_RS04235	877977..879446	+	1470	WP_000390454.1	virulence-associated E family protein	-
M013TW_RS04245	879732..880094	+	363	WP_001039168.1	hypothetical protein	-
M013TW_RS04250	880096..880380	+	285	WP_000998181.1	hypothetical protein	-
M013TW_RS04255	880377..881018	+	642	WP_001019764.1	hypothetical protein	-
M013TW_RS04260	881535..881876	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq / seb	853480..886827	33347

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T26108 WP_001103942.1 NC_016928:876707-877027 [Staphylococcus aureus subsp. aureus M013]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T26108 NC_016928:876707-877027 [Staphylococcus aureus subsp. aureus M013]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT26108 WP_001058486.1 NC_016928:876495-876704 [Staphylococcus aureus subsp. aureus M013]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT26108 NC_016928:876495-876704 [Staphylococcus aureus subsp. aureus M013]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4