261073

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3999210..3999829 Replicon chromosome
Accession NZ_CP107394
Organism Klebsiella pneumoniae strain CRKP_27

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag OH529_RS19585 Protein ID WP_002892050.1
Coordinates 3999210..3999428 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag OH529_RS19590 Protein ID WP_002892066.1
Coordinates 3999455..3999829 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH529_RS19550 3995257..3995520 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
OH529_RS19555 3995520..3995660 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
OH529_RS19560 3995657..3996355 - 699 WP_002892021.1 GNAT family protein -
OH529_RS19565 3996456..3997907 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
OH529_RS19570 3997882..3998352 - 471 WP_002892026.1 YlaC family protein -
OH529_RS19575 3998373..3998513 + 141 WP_004147370.1 hypothetical protein -
OH529_RS19580 3998485..3999051 - 567 WP_002892030.1 maltose O-acetyltransferase -
OH529_RS19585 3999210..3999428 - 219 WP_002892050.1 HHA domain-containing protein Toxin
OH529_RS19590 3999455..3999829 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
OH529_RS19595 4000315..4003461 - 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
OH529_RS19600 4003484..4004677 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T261073 WP_002892050.1 NZ_CP107394:c3999428-3999210 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT261073 WP_002892066.1 NZ_CP107394:c3999829-3999455 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References