Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3284042..3284558 Replicon chromosome
Accession NZ_CP107394
Organism Klebsiella pneumoniae strain CRKP_27

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag OH529_RS16160 Protein ID WP_002886902.1
Coordinates 3284274..3284558 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OH529_RS16155 Protein ID WP_002886901.1
Coordinates 3284042..3284284 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH529_RS16140 3280071..3280811 + 741 WP_002886899.1 KDGP aldolase family protein -
OH529_RS16145 3280877..3282031 + 1155 WP_002886900.1 lactonase family protein -
OH529_RS16150 3282054..3283964 + 1911 WP_004152270.1 PRD domain-containing protein -
OH529_RS16155 3284042..3284284 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OH529_RS16160 3284274..3284558 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OH529_RS16165 3284562..3285026 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OH529_RS16170 3285267..3287405 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
OH529_RS16175 3287762..3288505 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OH529_RS16180 3288508..3288681 - 174 WP_002886906.1 hypothetical protein -
OH529_RS16185 3288766..3289074 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T261071 WP_002886902.1 NZ_CP107394:3284274-3284558 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT261071 WP_002886901.1 NZ_CP107394:3284042-3284284 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References