Detailed information of TA system TA261070

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3126693..3128374
• Replicon: chromosome
• Accession: NZ_CP107394
• Organism: Klebsiella pneumoniae strain CRKP_27

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: W8V1Q6
• Locus tag: OH529_RS15360
• Protein ID: WP_002885155.1
• Coordinates: 3127457..3128374 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: W8UPQ8
• Locus tag: OH529_RS15355
• Protein ID: WP_004151732.1
• Coordinates: 3126693..3127451 (+)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OH529_RS15340	3122543..3123229	-	687	WP_004151733.1	tetratricopeptide repeat protein	-
OH529_RS15345	3123459..3125606	-	2148	WP_077598858.1	formate dehydrogenase subunit alpha	-
OH529_RS15350	3125879..3126607	+	729	WP_002885152.1	response regulator transcription factor	-
OH529_RS15355	3126693..3127451	+	759	WP_004151732.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
OH529_RS15360	3127457..3128374	+	918	WP_002885155.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
OH529_RS15365	3128499..3129506	-	1008	WP_004151731.1	carbohydrate kinase family protein	-
OH529_RS15370	3129581..3130522	-	942	WP_002885156.1	ABC transporter substrate-binding protein	-
OH529_RS15375	3130553..3131551	-	999	WP_002885172.1	ribose ABC transporter permease	-
OH529_RS15380	3131548..3133068	-	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34687.15 Da
• Isoelectric Point: 5.4707

>T261070 WP_002885155.1 NZ_CP107394:3127457-3128374 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28564.92 Da
• Isoelectric Point: 10.0870

>AT261070 WP_004151732.1 NZ_CP107394:3126693-3127451 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: A0A0H3GH11

Antitoxin

• AlphaFold DB: A0A0H3GQB5