Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 858800..859277 Replicon chromosome
Accession NC_016928
Organism Staphylococcus aureus subsp. aureus M013

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag M013TW_RS04075 Protein ID WP_000052076.1
Coordinates 858800..858988 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag M013TW_RS04080 Protein ID WP_001059690.1
Coordinates 859017..859277 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M013TW_RS04045 854838..855308 + 471 WP_000824462.1 hypothetical protein -
M013TW_RS04050 855649..856335 + 687 WP_001823812.1 thermonuclease family protein -
M013TW_RS04055 856692..856892 + 201 WP_001059082.1 cold-shock protein -
M013TW_RS04060 857391..857609 - 219 WP_000005888.1 hypothetical protein -
M013TW_RS04065 857671..857955 - 285 WP_001004397.1 hypothetical protein -
M013TW_RS04070 858043..858612 - 570 WP_001106657.1 hypothetical protein -
M013TW_RS04075 858800..858988 - 189 WP_000052076.1 hypothetical protein Toxin
M013TW_RS04080 859017..859277 - 261 WP_001059690.1 hypothetical protein Antitoxin
M013TW_RS04085 859618..859821 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
M013TW_RS04090 859818..860054 - 237 WP_000368687.1 hypothetical protein -
M013TW_RS04095 860279..860860 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
M013TW_RS04100 860933..861550 - 618 WP_000255554.1 LysE/ArgO family amino acid transporter -
M013TW_RS04105 861706..862200 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
M013TW_RS04110 862599..863021 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
M013TW_RS04115 863169..863885 + 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq / seb 853480..886827 33347


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T26107 WP_000052076.1 NC_016928:c858988-858800 [Staphylococcus aureus subsp. aureus M013]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T26107 NC_016928:c858988-858800 [Staphylococcus aureus subsp. aureus M013]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT26107 WP_001059690.1 NC_016928:c859277-859017 [Staphylococcus aureus subsp. aureus M013]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT26107 NC_016928:c859277-859017 [Staphylococcus aureus subsp. aureus M013]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References