Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2803664..2804289 Replicon chromosome
Accession NZ_CP107394
Organism Klebsiella pneumoniae strain CRKP_27

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OH529_RS13855 Protein ID WP_002882817.1
Coordinates 2803906..2804289 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OH529_RS13850 Protein ID WP_004150355.1
Coordinates 2803664..2803906 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH529_RS13825 2799655..2800254 + 600 WP_004151865.1 glucose-1-phosphatase -
OH529_RS13830 2800248..2801108 + 861 WP_002882807.1 virulence factor BrkB family protein -
OH529_RS13835 2801105..2801542 + 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OH529_RS13840 2801587..2802528 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OH529_RS13845 2802542..2803459 - 918 WP_002882812.1 alpha/beta hydrolase -
OH529_RS13850 2803664..2803906 + 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OH529_RS13855 2803906..2804289 + 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OH529_RS13860 2804463..2805392 - 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OH529_RS13865 2805389..2806024 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OH529_RS13870 2806021..2806923 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T261069 WP_002882817.1 NZ_CP107394:2803906-2804289 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT261069 WP_004150355.1 NZ_CP107394:2803664-2803906 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References