Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 91838..92481 Replicon plasmid unnamed1
Accession NZ_CP107391
Organism Klebsiella pneumoniae strain CRKP_28

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag OH501_RS27445 Protein ID WP_001044770.1
Coordinates 91838..92254 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag OH501_RS27450 Protein ID WP_001261282.1
Coordinates 92251..92481 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH501_RS27425 (87941) 87941..88213 - 273 Protein_110 transposase -
OH501_RS27435 (89195) 89195..90217 - 1023 WP_000361404.1 helicase UvrD -
OH501_RS27440 (90202) 90202..91764 - 1563 WP_004206609.1 AAA family ATPase -
OH501_RS27445 (91838) 91838..92254 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
OH501_RS27450 (92251) 92251..92481 - 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OH501_RS27455 (92438) 92438..92899 + 462 WP_014343465.1 hypothetical protein -
OH501_RS27460 (93060) 93060..94004 + 945 WP_011977810.1 hypothetical protein -
OH501_RS27465 (94041) 94041..94433 + 393 WP_011977811.1 hypothetical protein -
OH501_RS27470 (94491) 94491..95012 + 522 WP_013214008.1 hypothetical protein -
OH501_RS27475 (95058) 95058..95261 + 204 WP_011977813.1 hypothetical protein -
OH501_RS27480 (95291) 95291..96295 + 1005 WP_011977814.1 hypothetical protein -
OH501_RS27485 (96479) 96479..97258 + 780 WP_013214009.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid rmtB / blaTEM-1B / blaCTX-M-65 / blaKPC-2 - 1..155492 155492


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T261059 WP_001044770.1 NZ_CP107391:c92254-91838 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT261059 WP_001261282.1 NZ_CP107391:c92481-92251 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References