Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3332757..3333273 Replicon chromosome
Accession NZ_CP107390
Organism Klebsiella pneumoniae strain CRKP_28

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag OH501_RS16425 Protein ID WP_002886902.1
Coordinates 3332989..3333273 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OH501_RS16420 Protein ID WP_002886901.1
Coordinates 3332757..3332999 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH501_RS16405 3328786..3329526 + 741 WP_002886899.1 KDGP aldolase family protein -
OH501_RS16410 3329592..3330746 + 1155 WP_002886900.1 lactonase family protein -
OH501_RS16415 3330769..3332679 + 1911 WP_004152270.1 PRD domain-containing protein -
OH501_RS16420 3332757..3332999 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OH501_RS16425 3332989..3333273 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OH501_RS16430 3333277..3333741 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OH501_RS16435 3333982..3336120 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
OH501_RS16440 3336477..3337220 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OH501_RS16445 3337223..3337396 - 174 WP_002886906.1 hypothetical protein -
OH501_RS16450 3337481..3337789 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T261049 WP_002886902.1 NZ_CP107390:3332989-3333273 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT261049 WP_002886901.1 NZ_CP107390:3332757-3332999 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References